dc.contributor.author | Ferrer, Jorge M. | |
dc.contributor.author | Lang, Matthew J. | |
dc.contributor.author | Kamm, Roger Dale | |
dc.contributor.author | Lee, Hyungsuk | |
dc.date.accessioned | 2011-02-09T16:11:04Z | |
dc.date.available | 2011-02-09T16:11:04Z | |
dc.date.issued | 2010-07 | |
dc.date.submitted | 2010-03 | |
dc.identifier.issn | 1539-3755 | |
dc.identifier.issn | 1550-2376 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/60906 | |
dc.description.abstract | Two types of measurement are presented that relate molecular events to macroscopic behavior of F-actin networks. First, shear modulus is measured by oscillating an embedded microbead. Second, a microbead is translated at constant rate and transitions in the resisting force are observed. The loading rate dependence of the force at the transitions is similar to that of the molecular unbinding force, suggesting that they share a common origin. Reversibility tests of shear modulus provide further evidence that strain softening of F-actin networks is caused by force-induced rupture of cross-links. | en_US |
dc.description.sponsorship | National Institute of General Medical Sciences (U.S.) (GM076689) | en_US |
dc.description.sponsorship | National Science Foundation (U.S.) (0643745) | en_US |
dc.description.sponsorship | Nicholas Hobson Wheeles, Jr. Fund | en_US |
dc.description.sponsorship | W. M. Keck Foundation | en_US |
dc.description.sponsorship | Westaway Research Fund | en_US |
dc.description.sponsorship | Singapore-MIT Alliance for Research and Technology | en_US |
dc.language.iso | en_US | |
dc.publisher | American Physical Society | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1103/PhysRevE.82.011919 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | APS | en_US |
dc.title | Molecular origin of strain softening in cross-linked F-actin networks | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Lee, Hyungsuk et al. “Molecular origin of strain softening in cross-linked F-actin networks.” Physical Review E 82.1 (2010): 011919. © 2010 The American Physical Society. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | en_US |
dc.contributor.approver | Kamm, Roger Dale | |
dc.contributor.mitauthor | Ferrer, Jorge M. | |
dc.contributor.mitauthor | Lang, Matthew J. | |
dc.contributor.mitauthor | Kamm, Roger Dale | |
dc.contributor.mitauthor | Lee, Hyungsuk | |
dc.relation.journal | Physical Review E | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Lee, Hyungsuk; Ferrer, Jorge; Lang, Matthew; Kamm, Roger | en |
dc.identifier.orcid | https://orcid.org/0000-0002-4614-251X | |
dc.identifier.orcid | https://orcid.org/0000-0002-7232-304X | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |