Chondrogenic Differentiation of Adult Mesenchymal Stem Cells and Embryonic Stem Cells

Author(s)
Shu, K.; Thatte, H.; Spector, Myron
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Abstract
Mesenchymal stem cell (MSC) contraction associated with chondrogenesis is attributed to the expression of alpha-smooth muscle actin (alpha-SMA). In this study, pluripotent embryonic carcinoma cells (ECCs) and MSCs were compared for cartilage histogensis. Both cell types expressed alpha-SMA in monolayer. However, when cultured in pellets and in 3-D scaffolds, only MSCs contracted and formed glycosaminoglycan (GAG)- and type II collagen-rich tissue. Under these culture conditions, MSCs appear to be superior over ECCs for cartilage regeneration.
Date issued
2009-05
URI
http://hdl.handle.net/1721.1/61655
Department
Harvard University--MIT Division of Health Sciences and Technology
Journal
IEEE 35th Annual Northeast Bioengineering Conference, 2009
Publisher
Institute of Electrical and Electronics Engineers
Citation
Shu, K., H. Thatte, and M. Spector. “Chondrogenic differentiation of adult mesenchymal stem cells and embryonic stem cells.” Bioengineering Conference, 2009 IEEE 35th Annual Northeast. 2009. 1-2. © 2009 IEEE.
Version: Final published version
Other identifiers
INSPEC Accession Number: 10666570
ISBN
978-1-4244-4362-8
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