Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease

Author(s)
Diez Silva, Monica; Dao, Ming; Han, Jongyoon; Lim, Chwee Teck; Suresh, Subra
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Abstract
The biconcave shape and corresponding deformability of the human red blood cell (RBC) is an essential feature of its biological function. This feature of RBCs can be critically affected by genetic or acquired pathological conditions. In this review, we highlight new dynamic in vitro assays that explore various hereditary blood disorders and parasitic infectious diseases that cause disruption of RBC morphology and mechanics. In particular, recent advances in high-throughput microfluidic devices make it possible to sort/identify healthy and pathological human RBCs with different mechanobiological characteristics.
Date issued
2010-05
URI
http://hdl.handle.net/1721.1/64779
Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Department of Materials Science and Engineering
Journal
MRS Bulletin
Publisher
Materials Research Society
Citation
Diez-Silva, Monica et al. “Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease.” MRS Bulletin 35.05 (2011) : 382-388. Copyright © Materials Research Society 2010
Version: Final published version
ISSN
1938-1425
0883-7694
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