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Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease

dc.contributor.authorDiez Silva, Monica
dc.contributor.authorDao, Ming
dc.contributor.authorHan, Jongyoon
dc.contributor.authorLim, Chwee Teck
dc.contributor.authorSuresh, Subra
dc.date.accessioned2011-07-08T18:19:22Z
dc.date.available2011-07-08T18:19:22Z
dc.date.issued2010-05
dc.identifier.issn1938-1425
dc.identifier.issn0883-7694
dc.identifier.urihttp://hdl.handle.net/1721.1/64779
dc.description.abstractThe biconcave shape and corresponding deformability of the human red blood cell (RBC) is an essential feature of its biological function. This feature of RBCs can be critically affected by genetic or acquired pathological conditions. In this review, we highlight new dynamic in vitro assays that explore various hereditary blood disorders and parasitic infectious diseases that cause disruption of RBC morphology and mechanics. In particular, recent advances in high-throughput microfluidic devices make it possible to sort/identify healthy and pathological human RBCs with different mechanobiological characteristics.en_US
dc.description.sponsorshipSingapore-MIT Alliance for Research and Technologyen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01 HL094270-01A1)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant 1-R01-GM076689-01)en_US
dc.description.sponsorshipNational University of Singaporeen_US
dc.language.isoen_US
dc.publisherMaterials Research Societyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1557/mrs2010.571en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceMIT web domainen_US
dc.titleShape and Biomechanical Characteristics of Human Red Blood Cells in Health and Diseaseen_US
dc.typeArticleen_US
dc.identifier.citationDiez-Silva, Monica et al. “Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease.” MRS Bulletin 35.05 (2011) : 382-388. Copyright © Materials Research Society 2010en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.approverSuresh, Subra
dc.contributor.mitauthorDiez Silva, Monica
dc.contributor.mitauthorDao, Ming
dc.contributor.mitauthorHan, Jongyoon
dc.contributor.mitauthorSuresh, Subra
dc.relation.journalMRS Bulletinen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsDiez-Silva, Monica; Dao, Ming; Han, Jongyoon; Lim, Chwee-Teck; Suresh, Subraen
dc.identifier.orcidhttps://orcid.org/0000-0002-6223-6831
dc.identifier.orcidhttps://orcid.org/0000-0001-7215-1439
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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