A generative model for image segmentation based on label fusion
Author(s)Sabuncu, Mert R.; Yeo, Boon Thye Thomas; Fischl, Bruce; Van Leemput, Koen; Golland, Polina
MetadataShow full item record
We propose a nonparametric, probabilistic model for the automatic segmentation of medical images, given a training set of images and corresponding label maps. The resulting inference algorithms rely on pairwise registrations between the test image and individual training images. The training labels are then transferred to the test image and fused to compute the final segmentation of the test subject. Such label fusion methods have been shown to yield accurate segmentation, since the use of multiple registrations captures greater inter-subject anatomical variability and improves robustness against occasional registration failures. To the best of our knowledge, this manuscript presents the first comprehensive probabilistic framework that rigorously motivates label fusion as a segmentation approach. The proposed framework allows us to compare different label fusion algorithms theoretically and practically. In particular, recent label fusion or multiatlas segmentation algorithms are interpreted as special cases of our framework. We conduct two sets of experiments to validate the proposed methods. In the first set of experiments, we use 39 brain MRI scans - with manually segmented white matter, cerebral cortex, ventricles and subcortical structures - to compare different label fusion algorithms and the widely-used FreeSurfer whole-brain segmentation tool. Our results indicate that the proposed framework yields more accurate segmentation than FreeSurfer and previous label fusion algorithms. In a second experiment, we use brain MRI scans of 282 subjects to demonstrate that the proposed segmentation tool is sufficiently sensitive to robustly detect hippocampal volume changes in a study of aging and Alzheimer's Disease.
DepartmentMassachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
IEEE Transactions on Medical Imaging, 2010
Institute of Electrical and Electronics Engineers
Sabuncu, M.R. et al. “A Generative Model for Image Segmentation Based on Label Fusion.” Medical Imaging, IEEE Transactions On 29.10 (2010) : 1714-1729.© 2010 IEEE.
Final published version
INSPEC Accession Number: 11534908