Thalamocortical model for a propofol-induced alpha rhythm associated with loss of consciousness
Author(s)Ching, Shinung; Cimenser, Aylin; Purdon, Patrick Lee; Brown, Emery N.; Kopell, Nancy J.
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Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm [alpha rhythm] at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous α-activity [alpha activity]. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state.
DepartmentHarvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Proceedings of the National Academy of Sciences of the United States of America
National Academy of Sciences
Ching, S. et al. “Thalamocortical Model for a Propofol-induced -rhythm Associated with Loss of Consciousness.” Proceedings of the National Academy of Sciences 107.52 (2010) : 22665-22670.
Final published version