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Thalamocortical model for a propofol-induced alpha rhythm associated with loss of consciousness

Author(s)
Ching, Shinung; Cimenser, Aylin; Purdon, Patrick Lee; Brown, Emery N.; Kopell, Nancy J.
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Abstract
Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm [alpha rhythm] at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous α-activity [alpha activity]. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state.
Date issued
2010-12
URI
http://hdl.handle.net/1721.1/64815
Department
Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences
Citation
Ching, S. et al. “Thalamocortical Model for a Propofol-induced  -rhythm Associated with Loss of Consciousness.” Proceedings of the National Academy of Sciences 107.52 (2010) : 22665-22670.
Version: Final published version
ISSN
0027-8424
1091-6490

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