dc.contributor.author | Ching, Shinung | |
dc.contributor.author | Cimenser, Aylin | |
dc.contributor.author | Purdon, Patrick Lee | |
dc.contributor.author | Brown, Emery N. | |
dc.contributor.author | Kopell, Nancy J. | |
dc.date.accessioned | 2011-07-14T20:31:37Z | |
dc.date.available | 2011-07-14T20:31:37Z | |
dc.date.issued | 2010-12 | |
dc.date.submitted | 2010-08 | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.issn | 1091-6490 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/64815 | |
dc.description.abstract | Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm [alpha rhythm] at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous α-activity [alpha activity]. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant DP1-OD003646) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant K25-NS057580) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant DP2-OD006454) | en_US |
dc.description.sponsorship | National Science Foundation (U.S.) (Grant DMS-0717670) | en_US |
dc.language.iso | en_US | |
dc.publisher | National Academy of Sciences | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1073/pnas.1017069108 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PNAS | en_US |
dc.title | Thalamocortical model for a propofol-induced alpha rhythm associated with loss of consciousness | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Ching, S. et al. “Thalamocortical Model for a Propofol-induced -rhythm Associated with Loss of Consciousness.” Proceedings of the National Academy of Sciences 107.52 (2010) : 22665-22670. | en_US |
dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
dc.contributor.approver | Brown, Emery N. | |
dc.contributor.mitauthor | Ching, Shinung | |
dc.contributor.mitauthor | Cimenser, Aylin | |
dc.contributor.mitauthor | Purdon, Patrick Lee | |
dc.contributor.mitauthor | Brown, Emery N. | |
dc.relation.journal | Proceedings of the National Academy of Sciences of the United States of America | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Ching, S.; Cimenser, A.; Purdon, P. L.; Brown, E. N.; Kopell, N. J. | en |
dc.identifier.orcid | https://orcid.org/0000-0001-5651-5060 | |
dc.identifier.orcid | https://orcid.org/0000-0003-2668-7819 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |