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dc.contributor.authorChing, Shinung
dc.contributor.authorCimenser, Aylin
dc.contributor.authorPurdon, Patrick Lee
dc.contributor.authorBrown, Emery N.
dc.contributor.authorKopell, Nancy J.
dc.date.accessioned2011-07-14T20:31:37Z
dc.date.available2011-07-14T20:31:37Z
dc.date.issued2010-12
dc.date.submitted2010-08
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/1721.1/64815
dc.description.abstractRecent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm [alpha rhythm] at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous α-activity [alpha activity]. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant DP1-OD003646)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant K25-NS057580)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant DP2-OD006454)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Grant DMS-0717670)en_US
dc.language.isoen_US
dc.publisherNational Academy of Sciencesen_US
dc.relation.isversionofhttp://dx.doi.org/10.1073/pnas.1017069108en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePNASen_US
dc.titleThalamocortical model for a propofol-induced alpha rhythm associated with loss of consciousnessen_US
dc.typeArticleen_US
dc.identifier.citationChing, S. et al. “Thalamocortical Model for a Propofol-induced  -rhythm Associated with Loss of Consciousness.” Proceedings of the National Academy of Sciences 107.52 (2010) : 22665-22670.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.approverBrown, Emery N.
dc.contributor.mitauthorChing, Shinung
dc.contributor.mitauthorCimenser, Aylin
dc.contributor.mitauthorPurdon, Patrick Lee
dc.contributor.mitauthorBrown, Emery N.
dc.relation.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsChing, S.; Cimenser, A.; Purdon, P. L.; Brown, E. N.; Kopell, N. J.en
dc.identifier.orcidhttps://orcid.org/0000-0001-5651-5060
dc.identifier.orcidhttps://orcid.org/0000-0003-2668-7819
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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