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Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy

dc.contributor.authorRaja, Anju M.
dc.contributor.authorXu, Shuoyu
dc.contributor.authorSun, Wanxin
dc.contributor.authorZhou, Jianbiao
dc.contributor.authorTai, Dean C. S.
dc.contributor.authorChen, Chien Shing
dc.contributor.authorRajapakse, Jagath
dc.contributor.authorSo, Peter T. C.
dc.contributor.authorYu, Hanry
dc.date.accessioned2011-07-28T16:19:08Z
dc.date.available2011-07-28T16:19:08Z
dc.date.issued2010-10
dc.date.submitted2010-08
dc.identifier.issn1083-3668
dc.identifier.urihttp://hdl.handle.net/1721.1/64972
dc.description.abstractPulse-modulated second harmonic imaging microscopes (PM-SHIMs) exhibit improved signal-to-noise ratio (SNR) over conventional SHIMs on sensitive imaging and quantification of weak collagen signals inside tissues. We quantify the spatial distribution of sparse collagen inside a xenograft model of human acute myeloid leukemia (AML) tumor specimens treated with a new drug against receptor tyrosine kinase (ABT-869), and observe a significant increase in collagen area percentage, collagen fiber length, fiber width, and fiber number after chemotherapy. This finding reveals new insights into tumor responses to chemotherapy and suggests caution in developing new drugs and therapeutic regimens against cancers.en_US
dc.description.sponsorshipSingapore-MIT Alliance (Computational and Systems Biology Flagship Project)en_US
dc.description.sponsorshipSingapore. Agency for Science, Technology and Researchen_US
dc.description.sponsorshipSingapore. Biomedical Research Council (BMRC R185-001-045-305)en_US
dc.description.sponsorshipInstitute of Bioengineering and Nanotechnology (Singapore)en_US
dc.description.sponsorshipSingapore. Ministry of Educationen_US
dc.description.sponsorshipJassen Cilag (Firm) (R-185-000-182- 592)en_US
dc.description.sponsorshipSingapore-MIT Alliance (Computational and Systems Biology Flagship Project) (C-382-603-004-001)en_US
dc.description.sponsorshipSingapore. Mechanobiology Instituteen_US
dc.description.sponsorshipSingapore-MIT Alliance for Research and Technology. BioSystems and Micromechanicsen_US
dc.language.isoen_US
dc.publisherSociety of Photo-optical Instrumentation Engineersen_US
dc.relation.isversionofhttp://dx.doi.org/10.1117/1.3497565en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceSPIEen_US
dc.titlePulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapyen_US
dc.typeArticleen_US
dc.identifier.citationRaja, Anju M. et al. “Pulse-modulated Second Harmonic Imaging Microscope Quantitatively Demonstrates Marked Increase of Collagen in Tumor After Chemotherapy.” Journal of Biomedical Optics 15.5 (2010) : 056016. © 2010 SPIE.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.approverSo, Peter T. C.
dc.contributor.mitauthorRajapakse, Jagath
dc.contributor.mitauthorSo, Peter T. C.
dc.contributor.mitauthorYu, Hanry
dc.relation.journalJournal of Biomedical Opticsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsRaja, Anju M.; Xu, Shuoyu; Sun, Wanxin; Zhou, Jianbiao; Tai, Dean C. S.; Chen, Chien-Shing; Rajapakse, Jagath C.; So, Peter T. C.; Yu, Hanryen
dc.identifier.orcidhttps://orcid.org/0000-0002-0339-3685
dc.identifier.orcidhttps://orcid.org/0000-0003-4698-6488
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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