Light scattering of human red blood cells during metabolic remodeling of membrane
Author(s)Park, YongKeun; Dasari, Ramachandra Rao; Best-Popescu, Catherine A.; Popescu, Gabriel
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We present the light scattering properties of individual human red blood cells (RBCs). We show that both the RBC static and dynamic scattering signals are altered by adenosine 5’-triphosphate (ATP)-driven membrane metabolic remodeling. To measure the light scattering signal from individual RBCs, we use diffraction phase microscopy together with a Fourier transform light scattering technique. RBC cytosolic ATPs are both chemically and metabolically depleted, and the corresponding scattering signals are compared with the light scattering signal of normal RBCs having physiologic levels of ATP.
DepartmentHarvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Spectroscopy Laboratory
Journal of Biomedical Optics
Society of Photo-optical Instrumentation Engineers
Park, YongKeun et al. “Light Scattering of Human Red Blood Cells During Metabolic Remodeling of the Membrane.” Journal of Biomedical Optics 16.1 (2011) : 011013. © 2011 Society of Photo-Optical Instrumentation Engineers.
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