| dc.contributor.author | Gehring, Mary | |
| dc.contributor.author | Reik, Wolf | |
| dc.contributor.author | Henikoff, Steven | |
| dc.date.accessioned | 2011-10-13T13:30:20Z | |
| dc.date.available | 2011-10-13T13:30:20Z | |
| dc.date.issued | 2009-02 | |
| dc.identifier.issn | 0168-9525 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/66231 | |
| dc.description.abstract | Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant demethylation via the well-known DNA base-excision-repair process. Although the existence of active demethylation has been known for a longer time in mammals, the means of achieving it remain murky and mammals lack counterparts to the plant demethylases. Several intriguing experiments have indicated, but not conclusively proven, that DNA repair is also a plausible mechanism for animal demethylation. Here, we examine what is known from flowering plants about the pathways and function of enzymatic demethylation and discuss possible mechanisms whereby DNA repair might also underlie global demethylation in mammals. | en_US |
| dc.description.sponsorship | Life Sciences Research Foundation (Fellow) | en_US |
| dc.description.sponsorship | European Union (EU NoE The Epigenome) | en_US |
| dc.description.sponsorship | Biotechnology and Biological Sciences Research Council (Great Britain) | en_US |
| dc.description.sponsorship | Medical Research Council (Great Britain) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier Science Publishers | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/j.tig.2008.12.001 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | Gehring | en_US |
| dc.title | DNA demethylation by DNA repair | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Gehring, Mary, Wolf Reik, and Steven Henikoff. “DNA demethylation by DNA repair.” Trends in Genetics 25 (2009): 82-90. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.approver | Gehring, Mary | |
| dc.contributor.mitauthor | Gehring, Mary | |
| dc.relation.journal | Trends in Genetics | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Gehring, Mary; Reik, Wolf; Henikoff, Steven | en |
| dc.identifier.orcid | https://orcid.org/0000-0003-2280-1522 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
