| dc.contributor.author | Du, Pingwu | |
| dc.contributor.author | Lippard, Stephen J. | |
| dc.date.accessioned | 2011-12-14T20:49:01Z | |
| dc.date.available | 2011-12-14T20:49:01Z | |
| dc.date.issued | 2010-12 | |
| dc.date.submitted | 2010-08 | |
| dc.identifier.issn | 0020-1669 | |
| dc.identifier.issn | 1520-510X | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/67683 | |
| dc.description.abstract | We describe ZRL1, a turn-on colorimetric and red fluorescent zinc ion sensor. The Zn2+-promoted ring opening of the rhodamine spirolactam ring in ZRL1 evokes a 220-fold fluorescence turn-on response. In aqueous media, ZRL1 turn-on luminescence is highly selective for Zn2+ ions, with no significant response to other competitive cations, including Na+, K+, Ca2+, Mg2+, Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Cd2+, or Hg2+. In addition to these characteristics, preliminary results indicate that ZRL1 can be delivered to living cells and can be used to monitor changes in intracellular Zn2+ levels. | en_US |
| dc.description.sponsorship | National Institute of General Medical Sciences (U.S.) (GM065519) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/ic101569a | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | Prof. Lippard via Erja Kajosalo | en_US |
| dc.title | A Highly Selective Turn-On Colorimetric, Red Fluorescent Sensor for Detecting Mobile Zinc in Living Cells | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Du, Pingwu, and Stephen J. Lippard. “A Highly Selective Turn-On Colorimetric, Red Fluorescent Sensor for Detecting Mobile Zinc in Living Cells.” Inorganic Chemistry 49.23 (2010): 10753-10755. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.approver | Lippard, Stephen J. | |
| dc.contributor.mitauthor | Du, Pingwu | |
| dc.contributor.mitauthor | Lippard, Stephen J. | |
| dc.relation.journal | Inorganic Chemistry | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Du, Pingwu; Lippard, Stephen J. | en |
| dc.identifier.orcid | https://orcid.org/0000-0002-2693-4982 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
