Ratiometric and intensity-based zinc sensors built on rhodol and rhodamine platforms

Author(s)
Tomat, Elisa; Lippard, Stephen J.
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Abstract
A xanthene-forming condensation reaction yields rhodol and rhodamine dyes carrying a zinc-binding ligand that includes the aniline-type nitrogen donor of the fluorophores. Upon zinc coordination in neutral aqueous solution, rhodol RF3 behaves as a ratiometric sensor, and rhodamine RA1 acts as a turn-off intensity-based indicator. Both fluorescent compounds bind the divalent zinc cation with micromolar affinity.
Description
Synthetic procedures and product characterization data, zinc binding analysis methods, selectivity and pH dependence charts. This material is available free of charge via the Internet at http://pubs.acs.edu.
Date issued
2010-09
URI
http://hdl.handle.net/1721.1/67697
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Inorganic Chemistry
Publisher
American Chemical Society
Citation
Tomat, Elisa, and Stephen J. Lippard. “Ratiometric and Intensity-Based Zinc Sensors Built on Rhodol and Rhodamine Platforms.” Inorganic Chemistry 49 (2010): 9113-9115. Web. 15 Dec. 2011. © 2011 American Chemical Society
Version: Author's final manuscript
ISSN
0020-1669
1520-510X
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