Ratiometric and intensity-based zinc sensors built on rhodol and rhodamine platforms
Author(s)Tomat, Elisa; Lippard, Stephen J.
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A xanthene-forming condensation reaction yields rhodol and rhodamine dyes carrying a zinc-binding ligand that includes the aniline-type nitrogen donor of the fluorophores. Upon zinc coordination in neutral aqueous solution, rhodol RF3 behaves as a ratiometric sensor, and rhodamine RA1 acts as a turn-off intensity-based indicator. Both fluorescent compounds bind the divalent zinc cation with micromolar affinity.
Synthetic procedures and product characterization data, zinc binding analysis methods, selectivity and pH dependence charts. This material is available free of charge via the Internet at http://pubs.acs.edu.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society
Tomat, Elisa, and Stephen J. Lippard. “Ratiometric and Intensity-Based Zinc Sensors Built on Rhodol and Rhodamine Platforms.” Inorganic Chemistry 49 (2010): 9113-9115. Web. 15 Dec. 2011. © 2011 American Chemical Society
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