| dc.contributor.author | Goguen, Brenda N. | |
| dc.contributor.author | Hoffman, Brenton D. | |
| dc.contributor.author | Sellers, James R. | |
| dc.contributor.author | Schwartz, Martin A. | |
| dc.contributor.author | Imperiali, Barbara | |
| dc.date.accessioned | 2012-03-08T16:04:21Z | |
| dc.date.available | 2012-03-08T16:04:21Z | |
| dc.date.issued | 2011-06 | |
| dc.identifier.issn | 1433-7851 | |
| dc.identifier.issn | 1521-3773 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/69593 | |
| dc.description.abstract | Shining light on myosin: The incorporation of a caging group onto the essential phosphoserine residue of myosin by protein semisynthesis enables light-triggered activation of the protein (see picture). Caging eliminates the myosin activity, but exposure to 365 nm light restores its function to native levels. The caged protein can also be introduced into cells to facilitate studies of myosin with precise spatial and temporal resolution. | en_US |
| dc.description.sponsorship | American Heart Association (Fellowship) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH Cell Migration Consortium (GM064346)) | en_US |
| dc.description.sponsorship | National Institute of General Medical Sciences (U.S.) (Biotechnology Training Grant) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Wiley-VCH Verlag | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1002/anie.201100674 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike 3.0 | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ | en_US |
| dc.source | Prof. Imperiali via Erja Kajosalo | en_US |
| dc.title | Light-Triggered Myosin Activation for Probing Dynamic Cellular Processes | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Goguen, Brenda N. et al. “Light-Triggered Myosin Activation for Probing Dynamic Cellular Processes.” Angewandte Chemie International Edition 50.25 (2011): 5667–5670. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.approver | Imperiali, Barbara | |
| dc.contributor.mitauthor | Imperiali, Barbara | |
| dc.contributor.mitauthor | Goguen, Brenda N. | |
| dc.relation.journal | Angewandte Chemie International Edition | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Goguen, Brenda N.; Hoffman, Brenton D.; Sellers, James R.; Schwartz, Martin A.; Imperiali, Barbara | en |
| dc.identifier.orcid | https://orcid.org/0000-0002-5749-7869 | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
| mit.metadata.status | Complete | |
