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Structure of cholesterol helical ribbons and self-assembling biological springs

Author(s)
Khaykovich, Boris; Hossain, Chintan; McManus, Jennifer J.; Lomakin, Aleksey; Moncton, David E.; Benedek, George B.; ... Show more Show less
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Abstract
We report the results of x-ray-scattering studies of individual helical ribbons formed in multicomponent solutions of cholesterol solubilized by various surfactants. The solutions were chemically defined lipid concentrate (CDLC) and model bile. In these and many analogous multicomponent surfactant–cholesterol solutions, helical ribbons of two well defined pitch angles, namely 11° and 54°, are formed. We have suggested previously that this remarkable stability results from an underlying crystalline structure of the sterol ribbon strips. Using a synchrotron x-ray source, we have indeed observed Bragg reflections from individual ribbons having 11° pitch angle. We have been able to deduce the parameters of the unit cell. The crystal structure of these ribbons is similar to that of cholesterol monohydrate, with the important difference that the length of the unit cell perpendicular to the cholesterol layers is tripled. We discuss possible origins for this triplication as well as the connection between the crystalline structure and the geometrical form of the helical ribbons.
Date issued
2007-04
URI
http://hdl.handle.net/1721.1/69986
Department
MIT Materials Research Laboratory; Massachusetts Institute of Technology. Department of Materials Science and Engineering; Massachusetts Institute of Technology. Department of Physics; MIT Nuclear Reactor Laboratory
Journal
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences (PNAS)
Citation
Khaykovich, B. et al. “Structure of Cholesterol Helical Ribbons and Self-assembling Biological Springs.” Proceedings of the National Academy of Sciences 104.23 (2007): 9656–9660. Web. 11 Apr. 2012. © 2007 The National Academy of Sciences of the USA
Version: Final published version
ISSN
0027-8424
1091-6490

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