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dc.contributor.authorKhaykovich, Boris
dc.contributor.authorHossain, Chintan
dc.contributor.authorMcManus, Jennifer J.
dc.contributor.authorLomakin, Aleksey
dc.contributor.authorMoncton, David E.
dc.contributor.authorBenedek, George B.
dc.date.accessioned2012-04-11T18:53:19Z
dc.date.available2012-04-11T18:53:19Z
dc.date.issued2007-04
dc.date.submitted2007-02
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/1721.1/69986
dc.description.abstractWe report the results of x-ray-scattering studies of individual helical ribbons formed in multicomponent solutions of cholesterol solubilized by various surfactants. The solutions were chemically defined lipid concentrate (CDLC) and model bile. In these and many analogous multicomponent surfactant–cholesterol solutions, helical ribbons of two well defined pitch angles, namely 11° and 54°, are formed. We have suggested previously that this remarkable stability results from an underlying crystalline structure of the sterol ribbon strips. Using a synchrotron x-ray source, we have indeed observed Bragg reflections from individual ribbons having 11° pitch angle. We have been able to deduce the parameters of the unit cell. The crystal structure of these ribbons is similar to that of cholesterol monohydrate, with the important difference that the length of the unit cell perpendicular to the cholesterol layers is tripled. We discuss possible origins for this triplication as well as the connection between the crystalline structure and the geometrical form of the helical ribbons.en_US
dc.description.sponsorshipUnited States. Dept. of Energy. Office of Basic Energy Sciences (Award No. DE-FG02-04ER46149)en_US
dc.language.isoen_US
dc.publisherProceedings of the National Academy of Sciences (PNAS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1073/pnas.0702967104en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePNASen_US
dc.titleStructure of cholesterol helical ribbons and self-assembling biological springsen_US
dc.typeArticleen_US
dc.identifier.citationKhaykovich, B. et al. “Structure of Cholesterol Helical Ribbons and Self-assembling Biological Springs.” Proceedings of the National Academy of Sciences 104.23 (2007): 9656–9660. Web. 11 Apr. 2012. © 2007 The National Academy of Sciences of the USAen_US
dc.contributor.departmentMIT Materials Research Laboratoryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Physicsen_US
dc.contributor.departmentMIT Nuclear Reactor Laboratoryen_US
dc.contributor.approverBenedek, George B.
dc.contributor.mitauthorKhaykovich, Boris
dc.contributor.mitauthorHossain, Chintan
dc.contributor.mitauthorMcManus, Jennifer J.
dc.contributor.mitauthorLomakin, Aleksey
dc.contributor.mitauthorMoncton, David E.
dc.contributor.mitauthorBenedek, George B.
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsKhaykovich, B.; Hossain, C.; McManus, J. J.; Lomakin, A.; Moncton, D. E.; Benedek, G. B.en
dc.identifier.orcidhttps://orcid.org/0000-0002-9490-2771
dc.identifier.orcidhttps://orcid.org/0000-0003-2414-524X
dc.identifier.orcidhttps://orcid.org/0000-0001-6684-7608
mit.licenseMIT_AMENDMENTen_US
mit.metadata.statusComplete


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