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dc.contributor.authorRosen, Allyson C.
dc.contributor.authorSugiura, Lisa
dc.contributor.authorKramer, Joel H.
dc.contributor.authorGabrieli, Susan
dc.contributor.authorGabrieli, John D. E.
dc.date.accessioned2012-05-14T20:31:43Z
dc.date.available2012-05-14T20:31:43Z
dc.date.issued2011-08
dc.identifier.issn1875-8908
dc.identifier.issn1387-2877
dc.identifier.urihttp://hdl.handle.net/1721.1/70603
dc.description.abstractA randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. An auditory-verbal fMRI task was conducted before and after the two-month training program. Verbal memory scores improved significantly and left hippocampal activation increased significantly in the experimental group (gains in 5 of 6 participants) relative to the control group (reductions in all 6 participants). Results suggest that the hippocampus in MCI may retain sufficient neuroplasticity to benefit from cognitive training.en_US
dc.description.sponsorshipNational Institute on Aging (K01AG025157)en_US
dc.description.sponsorshipNational Institute on Aging (AG12995)en_US
dc.description.sponsorshipNational Institute on Aging (AG09466)en_US
dc.description.sponsorshipNational Institute on Aging (AG05865 01)en_US
dc.description.sponsorshipNational Institute of Mental Health (U.S.) (MH35182)en_US
dc.description.sponsorshipNational Institute of Mental Health (U.S.) (MH59940)en_US
dc.description.sponsorshipNational Center for Research Resources (U.S.) (RR09784)en_US
dc.description.sponsorshipPosit Science (Firm)en_US
dc.language.isoen_US
dc.publisherIOS Pressen_US
dc.relation.isversionofhttp://iospress.metapress.com/content/x083w76454777605/fulltext.pdfen_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePubMed Centralen_US
dc.titleCognitive training changes hippocampal function in mild cognitive impairment: A pilot studyen_US
dc.typeArticleen_US
dc.identifier.citationRosen, Allyson C. et al. "Cognitive Training Changes Hippocampal Function in Mild Cognitive Impairment: A Pilot Study." Journal of Alzheimer’s Disease 2011 ; 26(Suppl 3): 349–357.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.approverGabrieli, John D. E.
dc.contributor.mitauthorGabrieli, Susan
dc.contributor.mitauthorGabrieli, John D. E.
dc.relation.journalJournal of Alzheimer's Diseaseen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsRosen, Allyson C.; Sugiura, Lisa; Kramer, Joel H.; Whitfield-Gabrieli, Susan; Gabrieli, John D.en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1158-5692
mit.licenseOPEN_ACCESS_POLICYen_US


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