Room Temperature Aryl Trifluoromethylation via Copper- Mediated Oxidative Cross-Coupling
Author(s)Buchwald, Stephen Leffler; Senecal, Todd D.; Parsons, Andrew
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A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1−4 h. Proceeding under mild conditions, the method tolerates a range of functional groups, allowing access to a variety of trifluoromethylarenes.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Journal of Organic Chemistry
American Chemical Society (ACS)
Buchwald, Stephen Leffler, Andrew T. Parsons, and Todd D. Senecal. "Room Temperature Aryl Trifluoromethylation via Copper-Mediated Oxidative Cross-Coupling." The Journal of Organic Chemistry 76.4 (2011): 1174-1176.
Author's final manuscript