Room Temperature Aryl Trifluoromethylation via Copper- Mediated Oxidative Cross-Coupling

Author(s)
Buchwald, Stephen Leffler; Senecal, Todd D.; Parsons, Andrew
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Abstract
A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1−4 h. Proceeding under mild conditions, the method tolerates a range of functional groups, allowing access to a variety of trifluoromethylarenes.
Date issued
2011-01
URI
http://hdl.handle.net/1721.1/71959
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Citation
Buchwald, Stephen Leffler, Andrew T. Parsons, and Todd D. Senecal. "Room Temperature Aryl Trifluoromethylation via Copper-Mediated Oxidative Cross-Coupling." The Journal of Organic Chemistry 76.4 (2011): 1174-1176.
Version: Author's final manuscript
ISSN
0022-3263
1520-6904
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