Palladium-Catalyzed Amination of Unprotected Halo-7- azaindoles
Author(s)Henderson, Jaclyn L.; McDermott, Sarah M.; Buchwald, Stephen Leffler
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Simple and efficient procedures for the Pd-catalyzed cross-coupling of primary and secondary amines with halo-7-azaindoles(pyrrolo[2,3-b]pyridine) are presented. Previously, no general method was available to ensure the highly selective reaction of the heteroaryl halide in the presence of the unprotected azaindole N-H. Using palladium precatalysts recently reported by our group, such reactions are easily accomplished under mild conditions that can be applied to cross-coupling reactions with a wide array of aliphatic and aromatic amines.
DepartmentMassachusetts Institute of Technology. Department of Chemistry; Massachusetts Institute of Technology. Department of Humanities. History Section
American Chemical Society (ACS)
Henderson, Jaclyn L., Sarah M. McDermott, and Stephen L. Buchwald. “Palladium-Catalyzed Amination of Unprotected Halo-7-azaindoles.” Organic Letters 12.20 (2010): 4438–4441.
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