Nickel-Catalyzed Allylic Substitution of Simple Alkenes
Author(s)Matsubara, Ryosuke; Jamison, Timothy F.
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This report describes a nickel-catalyzed allylic substitution process of simple alkenes whereby an important structural motif, a 1,4-diene, was prepared. The key to success is the use of an appropriate nickel–phosphine complex and a stoichiometric amount of silyl triflate. Reactions of 1-alkyl-substituted alkenes consistently provided 1,1-disubstituted alkenes with high selectivity. Insight into the reaction mechanism as well as miscellaneous application of the developed catalytic process is also documented.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Chemistry - An Asian Journal
Wiley Blackwell (John Wiley & Sons)
Matsubara, Ryosuke, and Timothy F. Jamison. “Nickel-Catalyzed Allylic Substitution of Simple Alkenes.” Chemistry - An Asian Journal 6.7 (2011): 1860–1875.
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