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Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells

Author(s)
Zhou, Chao; Tsai, Tsung-Han; Adler, Desmond C.; Lee, Hsiang-Chieh; Cohen, David W.; Mondelblatt, Amy E.; Wang, Yihong; Connolly, James L.; Fujimoto, James G.; ... Show more Show less
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Abstract
We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300–600 μm deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells.
Date issued
2010-02
URI
http://hdl.handle.net/1721.1/72161
Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Journal
Optics Letters
Publisher
Optical Society of America
Citation
Zhou, Chao et al. “Photothermal Optical Coherence Tomography in Ex Vivo Human Breast Tissues Using Gold Nanoshells.” Optics Letters 35.5 (2010): 700.
Version: Author's final manuscript
ISSN
0146-9592
1539-4794

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