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Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells

dc.contributor.authorZhou, Chao
dc.contributor.authorTsai, Tsung-Han
dc.contributor.authorAdler, Desmond C.
dc.contributor.authorLee, Hsiang-Chieh
dc.contributor.authorCohen, David W.
dc.contributor.authorMondelblatt, Amy E.
dc.contributor.authorWang, Yihong
dc.contributor.authorConnolly, James L.
dc.contributor.authorFujimoto, James G.
dc.date.accessioned2012-08-15T19:21:36Z
dc.date.available2012-08-15T19:21:36Z
dc.date.issued2010-02
dc.date.submitted2009-11
dc.identifier.issn0146-9592
dc.identifier.issn1539-4794
dc.identifier.urihttp://hdl.handle.net/1721.1/72161
dc.description.abstractWe demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300–600 μm deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant Number R01- CA75289-13)en_US
dc.description.sponsorshipUnited States. Air Force Office of Scientific Research (Contract Number FA9550-07-1-0014)en_US
dc.description.sponsorshipMFELP (Contract Number FA9550-07-1-0101)en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada (NSERC) Heritage Scholarship Funden_US
dc.description.sponsorshipCenter for Integration of Medicine and Innovative Technologyen_US
dc.description.sponsorshipNational Science council of Taiwan. Taiwan Merit Scholarshipen_US
dc.language.isoen_US
dc.publisherOptical Society of Americaen_US
dc.relation.isversionofhttp://dx.doi.org/10.1364/OL.35.000700en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePubMed Centralen_US
dc.titlePhotothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshellsen_US
dc.typeArticleen_US
dc.identifier.citationZhou, Chao et al. “Photothermal Optical Coherence Tomography in Ex Vivo Human Breast Tissues Using Gold Nanoshells.” Optics Letters 35.5 (2010): 700.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.approverFujimoto, James G.
dc.contributor.mitauthorZhou, Chao
dc.contributor.mitauthorTsai, Tsung-Han
dc.contributor.mitauthorAdler, Desmond C.
dc.contributor.mitauthorLee, Hsiang-Chieh
dc.contributor.mitauthorFujimoto, James G.
dc.relation.journalOptics Lettersen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsZhou, Chao; Tsai, Tsung-Han; Adler, Desmond C.; Lee, Hsiang-Chieh; Cohen, David W.; Mondelblatt, Amy; Wang, Yihong; Connolly, James L.; Fujimoto, James G.en
dc.identifier.orcidhttps://orcid.org/0000-0002-0828-4357
dc.identifier.orcidhttps://orcid.org/0000-0002-2976-6195
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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