Protein knot server: detection of knots in protein structures
Author(s)Kolesov, Grigory; Virnau, Peter; Kardar, Mehran; Mirny, Leonid A.
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KNOTS (http://knots.mit.edu) is a web server that detects knots in protein structures. Several protein structures have been reported to contain intricate knots. The physiological role of knots and their effect on folding and evolution is an area of active research. The user submits a PDB id or uploads a 3D protein structure in PDB or mmCIF format. The current implementation of the server uses the Alexander polynomial to detect knots. The results of the analysis that are presented to the user are the location of the knot in the structure, the type of the knot and an interactive visualization of the knot. The results can also be downloaded and viewed offline. The server also maintains a regularly updated list of known knots in protein structures.
DepartmentWhitaker College of Health Sciences and Technology; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Physics
Nucleic Acids Research
Oxford University Press
Kolesov, G. et al. “Protein Knot Server: Detection of Knots in Protein Structures.” Nucleic Acids Research 35.Web Server (2007): W425–W428. Web.
Final published version