Protein knot server: detection of knots in protein structures

Author(s)
Kolesov, Grigory; Virnau, Peter; Kardar, Mehran; Mirny, Leonid A.
Thumbnail
DownloadKolesov-2007-Protein knot server.pdf (1.650Mb)
PUBLISHER_CC
Terms of use
Creative Commons Attribution Non-Commercial http://creativecommons.org/licenses/by-nc/2.5
Metadata
Show full item record
Abstract
KNOTS (http://knots.mit.edu) is a web server that detects knots in protein structures. Several protein structures have been reported to contain intricate knots. The physiological role of knots and their effect on folding and evolution is an area of active research. The user submits a PDB id or uploads a 3D protein structure in PDB or mmCIF format. The current implementation of the server uses the Alexander polynomial to detect knots. The results of the analysis that are presented to the user are the location of the knot in the structure, the type of the knot and an interactive visualization of the knot. The results can also be downloaded and viewed offline. The server also maintains a regularly updated list of known knots in protein structures.
Date issued
2007-05
URI
http://hdl.handle.net/1721.1/72331
Department
Whitaker College of Health Sciences and Technology; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Physics
Journal
Nucleic Acids Research
Publisher
Oxford University Press
Citation
Kolesov, G. et al. “Protein Knot Server: Detection of Knots in Protein Structures.” Nucleic Acids Research 35.Web Server (2007): W425–W428. Web.
Version: Final published version
ISSN
0305-1048
1362-4962
Collections