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dc.contributor.authorKolesov, Grigory
dc.contributor.authorVirnau, Peter
dc.contributor.authorKardar, Mehran
dc.contributor.authorMirny, Leonid A.
dc.date.accessioned2012-08-22T20:06:05Z
dc.date.available2012-08-22T20:06:05Z
dc.date.issued2007-05
dc.date.submitted2007-04
dc.identifier.issn0305-1048
dc.identifier.issn1362-4962
dc.identifier.urihttp://hdl.handle.net/1721.1/72331
dc.description.abstractKNOTS (http://knots.mit.edu) is a web server that detects knots in protein structures. Several protein structures have been reported to contain intricate knots. The physiological role of knots and their effect on folding and evolution is an area of active research. The user submits a PDB id or uploads a 3D protein structure in PDB or mmCIF format. The current implementation of the server uses the Alexander polynomial to detect knots. The results of the analysis that are presented to the user are the location of the knot in the structure, the type of the knot and an interactive visualization of the knot. The results can also be downloaded and viewed offline. The server also maintains a regularly updated list of known knots in protein structures.en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (grant DMR-04-26677)en_US
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG) (grant VI237/1)en_US
dc.description.sponsorshipAlfred P. Sloan Foundation (Research Fellowship)en_US
dc.language.isoen_US
dc.publisherOxford University Pressen_US
dc.relation.isversionofhttp://dx.doi.org/10.1093/nar/gkm312en_US
dc.rightsCreative Commons Attribution Non-Commercialen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.5en_US
dc.sourceOxforden_US
dc.titleProtein knot server: detection of knots in protein structuresen_US
dc.typeArticleen_US
dc.identifier.citationKolesov, G. et al. “Protein Knot Server: Detection of Knots in Protein Structures.” Nucleic Acids Research 35.Web Server (2007): W425–W428. Web.en_US
dc.contributor.departmentWhitaker College of Health Sciences and Technologyen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Physicsen_US
dc.contributor.approverMirny, Leonid A.
dc.contributor.mitauthorMirny, Leonid A.
dc.contributor.mitauthorKolesov, Grigory
dc.contributor.mitauthorKardar, Mehran
dc.contributor.mitauthorVirnau, Peter
dc.relation.journalNucleic Acids Researchen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsKolesov, G.; Virnau, P.; Kardar, M.; Mirny, L. A.en
dc.identifier.orcidhttps://orcid.org/0000-0002-0785-5410
dc.identifier.orcidhttps://orcid.org/0000-0002-1112-5912
mit.licensePUBLISHER_CCen_US


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