dc.contributor.author | Kim, Youngchan | |
dc.contributor.author | Higgins, John M. | |
dc.contributor.author | Dasari, Ramachandra Rao | |
dc.contributor.author | Suresh, Subra | |
dc.contributor.author | Park, YongKeun | |
dc.date.accessioned | 2012-08-27T17:52:14Z | |
dc.date.available | 2012-08-27T17:52:14Z | |
dc.date.issued | 2012-04 | |
dc.date.submitted | 2012-01 | |
dc.identifier.issn | 1083-3668 | |
dc.identifier.issn | 1560-2281 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/72348 | |
dc.description.abstract | We present the anisotropic light scattering of individual red blood cells (RBCs) from a patient with sickle cell disease (SCD). To measure light scattering spectra along two independent axes of elongated-shaped sickle RBCs with arbitrary orientation, we introduce the anisotropic Fourier transform light scattering (aFTLS) technique and measured both the static and dynamic anisotropic light scattering. We observed strong anisotropy in light scattering patterns of elongated-shaped sickle RBCs along its major axes using static aFTLS. Dynamic aFTLS analysis reveals the significantly altered biophysical properties in individual sickle RBCs. These results provide evidence that effective viscosity and elasticity of sickle RBCs are significantly different from those of the healthy RBCs. | en_US |
dc.description.sponsorship | Korea Advanced Institute of Science and Technology (N10110038) | en_US |
dc.description.sponsorship | Korea Advanced Institute of Science and Technology (N10110048) | en_US |
dc.description.sponsorship | Korea Advanced Institute of Science and Technology (G04100075) | en_US |
dc.description.sponsorship | Korea (South). Ministry of Education, Science and Technology (MEST) (Grant number 2009-0087691) | en_US |
dc.description.sponsorship | National Research Foundation of Korea (NRF-2011-355-c00039) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (P41-RR02594-18-24) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (R01HL094270) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (DK083242) | en_US |
dc.language.iso | en_US | |
dc.publisher | SPIE | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1117/1.jbo.17.4.040501 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | SPIE | en_US |
dc.title | Anisotropic light scattering of individual sickle red blood cells | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Kim, Youngchan et al. “Anisotropic Light Scattering of Individual Sickle Red Blood Cells.” Journal of Biomedical Optics 17.4 (2012): 040501. © 2012 Society of Photo-Optical Instrumentation Engineers | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Materials Science and Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Spectroscopy Laboratory | en_US |
dc.contributor.approver | Suresh, Subra | |
dc.contributor.mitauthor | Dasari, Ramachandra Rao | |
dc.contributor.mitauthor | Suresh, Subra | |
dc.relation.journal | Journal of Biomedical Optics | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Kim, Youngchan; Higgins, John M.; Dasari, Ramachandra R.; Suresh, Subra; Park, YongKeun | en |
dc.identifier.orcid | https://orcid.org/0000-0002-6223-6831 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |