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Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells

dc.contributor.authorStaerk, Judith
dc.contributor.authorLyssiotis, Costas A.
dc.contributor.authorMedeiro, Lea A.
dc.contributor.authorBollong, Michael
dc.contributor.authorForeman, Ruth K.
dc.contributor.authorZhu, Shoutian
dc.contributor.authorGarcia, Michael
dc.contributor.authorGao, Qing
dc.contributor.authorBouchez, Laure C.
dc.contributor.authorLairson, Luke L.
dc.contributor.authorCharette, Bradley D.
dc.contributor.authorSupekova, Lubica
dc.contributor.authorJanes, Jeffrey
dc.contributor.authorBrinker, Achim
dc.contributor.authorCho, Charles Y.
dc.contributor.authorJaenisch, Rudolf
dc.contributor.authorSchultz, Peter G.
dc.date.accessioned2012-09-28T16:48:43Z
dc.date.available2012-09-28T16:48:43Z
dc.date.issued2011-05
dc.date.submitted2011-02
dc.identifier.issn1433-7851
dc.identifier.issn1521-3773
dc.identifier.urihttp://hdl.handle.net/1721.1/73479
dc.description.abstractSmall molecules do the job: Somatic cells are reprogrammed into iPS cells upon ectopic expression of Oct4, Sox2, Klf4 and c-Myc. Application of a cell-based, high-throughput chemical screen led to the identification of Src family kinase (SFK) inhibitors as chemical replacements for retroviral Sox2 delivery. These compounds are used to study the mechanisms underlying direct reprogramming and may ultimately help to bring iPS cell technology one step closer to clinical application.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant HD 045022)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant 5 R37A084198)en_US
dc.language.isoen_US
dc.publisherWiley Blackwell (John Wiley & Sons)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/anie.201101042en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePMCen_US
dc.titlePan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cellsen_US
dc.typeArticleen_US
dc.identifier.citationStaerk, Judith et al. “Pan-Src Family Kinase Inhibitors Replace Sox2 During the Direct Reprogramming of Somatic Cells.” Angewandte Chemie International Edition 50.25 (2011): 5734–5736.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.mitauthorForeman, Ruth K.
dc.contributor.mitauthorJaenisch, Rudolf
dc.relation.journalAngewandte Chemie International Editionen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsStaerk, Judith; Lyssiotis, Costas A.; Medeiro, Lea A.; Bollong, Michael; Foreman, Ruth K.; Zhu, Shoutian; Garcia, Michael; Gao, Qing; Bouchez, Laure C.; Lairson, Luke L.; Charette, Bradley D.; Supekova, Lubica; Janes, Jeffrey; Brinker, Achim; Cho, Charles Y.; Jaenisch, Rudolf; Schultz, Peter G.en
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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