The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
Author(s)Stewart, Michelle L.; Fire, Emiko; Keating, Amy E.; Walensky, Loren D.
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MCL-1 has emerged as a major oncogenic and chemoresistance factor. A screen of stapled peptide helices identified the MCL-1 BH3 domain as selectively inhibiting MCL-1 among the related anti-apoptotic Bcl-2 family members, providing insights into the molecular determinants of binding specificity and a new approach for sensitizing cancer cells to apoptosis.
available in PMC 2011 February 3.
DepartmentMassachusetts Institute of Technology. Department of Biology
Nature Chemical Biology
Nature Publishing Group
Stewart, Michelle L et al. “The MCL-1 BH3 Helix Is an Exclusive MCL-1 Inhibitor and Apoptosis Sensitizer.” Nature Chemical Biology 6.8 (2010): 595–601. Web.
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