| dc.contributor.author | Stewart, Michelle L. | |
| dc.contributor.author | Fire, Emiko | |
| dc.contributor.author | Keating, Amy E. | |
| dc.contributor.author | Walensky, Loren D. | |
| dc.date.accessioned | 2012-10-15T14:56:06Z | |
| dc.date.available | 2012-10-15T14:56:06Z | |
| dc.date.issued | 2010-08 | |
| dc.identifier.issn | 1552-4450 | |
| dc.identifier.issn | 1552-4469 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/73960 | |
| dc.description | available in PMC 2011 February 3. | en_US |
| dc.description.abstract | MCL-1 has emerged as a major oncogenic and chemoresistance factor. A screen of stapled peptide helices identified the MCL-1 BH3 domain as selectively inhibiting MCL-1 among the related anti-apoptotic Bcl-2 family members, providing insights into the molecular determinants of binding specificity and a new approach for sensitizing cancer cells to apoptosis. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH award 5RO1GM084181) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH grant 5P01CA92625) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award 1F31CA144566) | en_US |
| dc.description.sponsorship | Burroughs Wellcome Fund (Career Award) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Nature Publishing Group | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1038/nchembio.391 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike 3.0 | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Stewart, Michelle L et al. “The MCL-1 BH3 Helix Is an Exclusive MCL-1 Inhibitor and Apoptosis Sensitizer.” Nature Chemical Biology 6.8 (2010): 595–601. Web. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.mitauthor | Keating, Amy E. | |
| dc.contributor.mitauthor | Fire, Emiko | |
| dc.relation.journal | Nature Chemical Biology | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Stewart, Michelle L; Fire, Emiko; Keating, Amy E; Walensky, Loren D | en |
| dc.identifier.orcid | https://orcid.org/0000-0003-4074-8980 | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
| mit.metadata.status | Complete | |
