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dc.contributor.authorLiu, Jonathan Jaoshin
dc.contributor.authorPotsaid, Benjamin M.
dc.contributor.authorChen, Yueli
dc.contributor.authorGorczynska, Iwona
dc.contributor.authorSrinivasan, Vivek J.
dc.contributor.authorDuker, Jay S.
dc.contributor.authorFujimoto, James G.
dc.date.accessioned2012-10-15T15:25:32Z
dc.date.available2012-10-15T15:25:32Z
dc.date.issued2010-03
dc.identifier.issn0277-786X
dc.identifier.urihttp://hdl.handle.net/1721.1/73963
dc.description.abstractWe performed OCT imaging of the rat retina at 70,000 axial scans per second with ~3 μm axial resolution. Three-dimensional OCT (3D-OCT) data sets of the rat retina were acquired. The high speed and high density data sets enable improved en face visualization by reducing eye motion artifacts and improve Doppler OCT measurements. Minimal motion artifacts were visible and the OCT fundus images offer more precise registration of individual OCT images to retinal fundus features. Projection OCT fundus images show features such as the nerve fiber layer, retinal capillary networks and choroidal vasculature. Doppler OCT images and quantitative measurements show pulsatility in retinal blood vessels. Doppler OCT provides noninvasive in vivo quantitative measurements of retinal blood flow properties and may benefit studies of diseases such as glaucoma and diabetic retinopathy. Ultrahigh speed imaging using ultrahigh resolution spectral / Fourier domain OCT promises to enable novel protocols for measuring small animal retinal structure and retinal blood flow. This non-invasive imaging technology is a promising tool for monitoring disease progression in rat and mouse models to assess ocular disease pathogenesis and response to treatment.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Contract 5R01-EY011289-23)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Contract 5R01-EY013178-09)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Contract 2R01-EY013516-16)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Contract 1R01-EY019029-01)en_US
dc.description.sponsorshipUnited States. Air Force Office of Scientific Research (FA9550-07-1-0101)en_US
dc.description.sponsorshipUnited States. Air Force Office of Scientific Research (FA9550-07-1-0014)en_US
dc.language.isoen_US
dc.publisherSPIEen_US
dc.relation.isversionofhttp://dx.doi.org/10.1117/12.842540en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceSPIEen_US
dc.titleUltrahigh Speed Imaging of the Rat Retina Using Ultrahigh Resolution Spectral/Fourier Domain OCTen_US
dc.typeArticleen_US
dc.identifier.citationJonathan J. Liu ; Benjamin Potsaid ; Yueli Chen ; Iwona Gorczynska ; Vivek J. Srinivasan ; Jay S. Duker ; James G. Fujimoto; Ultrahigh-speed imaging of the rat retina using ultrahigh-resolution spectral/Fourier domain OCT. Proc. SPIE 7550, Ophthalmic Technologies XX, 755017 (March 02, 2010). SPIE © 2010en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.contributor.mitauthorLiu, Jonathan Jaoshin
dc.contributor.mitauthorPotsaid, Benjamin M.
dc.contributor.mitauthorChen, Yueli
dc.contributor.mitauthorGorczynska, Iwona
dc.contributor.mitauthorSrinivasan, Vivek J.
dc.contributor.mitauthorFujimoto, James G.
dc.relation.journalProceedings of SPIE--the International Society for Optical Engineeringen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsLiu, Jonathan J.; Potsaid, Benjamin; Chen, Yueli; Gorczynska, Iwona; Srinivasan, Vivek J.; Duker, Jay S.; Fujimoto, James G.en
dc.identifier.orcidhttps://orcid.org/0000-0002-0828-4357
mit.licensePUBLISHER_POLICYen_US


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