Rapamycin inhibits mTORC1, but not completely

Author(s)
Thoreen, Carson C; Sabatini, David
Thumbnail
DownloadSabatini_Rapamycin inhibits.pdf (585.9Kb)
PUBLISHER_CC
Terms of use
Metadata
Show full item record
Abstract
Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.
Date issued
2009-07
URI
http://hdl.handle.net/1721.1/74547
Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Journal
Autophagy
Publisher
Landes Bioscience
Citation
Thoreen, Carson C., and David M. Sabatini. “Rapamycin Inhibits mTORC1, but Not Completely.” Autophagy 5.5 (2009): 725–727. © 2009 Landes Bioscience
Version: Final published version
ISSN
1554-8627
Collections