Rapamycin inhibits mTORC1, but not completely
Author(s)Thoreen, Carson C.; Sabatini, David M.
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Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.
DepartmentMassachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Thoreen, Carson C., and David M. Sabatini. “Rapamycin Inhibits mTORC1, but Not Completely.” Autophagy 5.5 (2009): 725–727. © 2009 Landes Bioscience
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