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Rapamycin inhibits mTORC1, but not completely

dc.contributor.authorThoreen, Carson C
dc.contributor.authorSabatini, David
dc.date.accessioned2012-11-01T17:11:51Z
dc.date.available2012-11-01T17:11:51Z
dc.date.issued2009-07
dc.date.submitted2009-03
dc.identifier.issn1554-8627
dc.identifier.urihttp://hdl.handle.net/1721.1/74547
dc.description.abstractRapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.en_US
dc.language.isoen_US
dc.publisherLandes Bioscienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.4161/auto.5.5.8504en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en_US
dc.sourceLandes Bioscienceen_US
dc.titleRapamycin inhibits mTORC1, but not completelyen_US
dc.typeArticleen_US
dc.identifier.citationThoreen, Carson C., and David M. Sabatini. “Rapamycin Inhibits mTORC1, but Not Completely.” Autophagy 5.5 (2009): 725–727. © 2009 Landes Bioscienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.mitauthorThoreen, Carson C.
dc.contributor.mitauthorSabatini, David M.
dc.relation.journalAutophagyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsThoreen, Carson C.; Sabatini, David M.en
dc.identifier.orcidhttps://orcid.org/0000-0002-1446-7256
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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