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dc.contributor.authorSambanthamurthi, Ravigadevi
dc.contributor.authorTan, YewAi
dc.contributor.authorSundram, Kalyana
dc.contributor.authorHayes, Kenneth C.
dc.contributor.authorAbeywardena, Mahinda
dc.contributor.authorLeow, Soon-Sen
dc.contributor.authorSekaran, Shamala Devi
dc.contributor.authorSubramaniam, Krishnan
dc.contributor.authorFairus, Syed
dc.contributor.authorWahid, Mohd Basri
dc.contributor.authorSambandan, T G
dc.contributor.authorRha, Chokyun
dc.contributor.authorSinskey, Anthony J
dc.date.accessioned2012-11-13T16:07:52Z
dc.date.available2012-11-13T16:07:52Z
dc.date.issued2011-06
dc.date.submitted2011-03
dc.identifier.issn0007-1145
dc.identifier.issn1475-2662
dc.identifier.urihttp://hdl.handle.net/1721.1/74627
dc.description.abstractIt is well established that plant phenolics elicit various biological activities, with positive effects on health. Palm oil production results in large volumes of aqueous by-products containing phenolics. In the present study, we describe the effects of oil palm phenolics (OPP) on several degenerative conditions using various animal models. OPP reduced blood pressure in a NO-deficient rat model, protected against ischaemia-induced cardiac arrhythmia in rats and reduced plaque formation in rabbits fed an atherogenic diet. In Nile rats, a spontaneous model of the metabolic syndrome and type 2 diabetes, OPP protected against multiple aspects of the syndrome and diabetes progression. In tumour-inoculated mice, OPP protected against cancer progression. Microarray studies on the tumours showed differential transcriptome profiles that suggest anti-tumour molecular mechanisms involved in OPP action. Thus, initial studies suggest that OPP may have potential against several chronic disease outcomes in mammals.en_US
dc.language.isoen_US
dc.publisherCambridge University Pressen_US
dc.relation.isversionofhttp://dx.doi.org/10.1017/S0007114511002133en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceMIT web domainen_US
dc.titlePositive outcomes of oil palm phenolics on degenerative diseases in animal modelsen_US
dc.typeArticleen_US
dc.identifier.citationSambanthamurthi, Ravigadevi et al. “Positive Outcomes of Oil Palm Phenolics on Degenerative Diseases in Animal Models.” British Journal of Nutrition 106.11 (2011): 1664–1675. © Cambridge University Press 2011en_US
dc.contributor.departmentMassachusetts Institute of Technology. Biomaterials Science and Engineering Laboratoryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorSambandan, T. G.
dc.contributor.mitauthorRha, ChoKyun
dc.contributor.mitauthorSinskey, Anthony J.
dc.relation.journalBritish Journal of Nutritionen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsSambanthamurthi, Ravigadevi; Tan, YewAi; Sundram, Kalyana; Hayes, Kenneth C.; Abeywardena, Mahinda; Leow, Soon-Sen; Devi Sekaran, Shamala; Sambandan, T. G.; Rha, ChoKyun; Sinskey, Anthony J.; Subramaniam, Krishnan; Fairus, Syed; Basri Wahid, Mohden
dc.identifier.orcidhttps://orcid.org/0000-0002-1015-1270
dc.identifier.orcidhttps://orcid.org/0000-0002-6671-5987
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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