Positive outcomes of oil palm phenolics on degenerative diseases in animal models
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Sinskey_Positive outcomes.pdf
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Author(s)
Sambanthamurthi, Ravigadevi
Tan, YewAi
Sundram, Kalyana
Hayes, Kenneth C.
Abeywardena, Mahinda
Leow, Soon-Sen
Sekaran, Shamala Devi
Subramaniam, Krishnan
Fairus, Syed
Wahid, Mohd Basri
Date Issued
June 2011
Journal
British Journal of Nutrition
Publisher
Cambridge University Press
Citation
Sambanthamurthi, Ravigadevi et al. “Positive Outcomes of Oil Palm Phenolics on Degenerative Diseases in Animal Models.” British Journal of Nutrition 106.11 (2011): 1664–1675. © Cambridge University Press 2011
Version
Final published version
Abstract
It is well established that plant phenolics elicit various biological activities, with positive effects on health. Palm oil production results in large volumes of aqueous by-products containing phenolics. In the present study, we describe the effects of oil palm phenolics (OPP) on several degenerative conditions using various animal models. OPP reduced blood pressure in a NO-deficient rat model, protected against ischaemia-induced cardiac arrhythmia in rats and reduced plaque formation in rabbits fed an atherogenic diet. In Nile rats, a spontaneous model of the metabolic syndrome and type 2 diabetes, OPP protected against multiple aspects of the syndrome and diabetes progression. In tumour-inoculated mice, OPP protected against cancer progression. Microarray studies on the tumours showed differential transcriptome profiles that suggest anti-tumour molecular mechanisms involved in OPP action. Thus, initial studies suggest that OPP may have potential against several chronic disease outcomes in mammals.
MIT Department
Massachusetts Institute of Technology. Biomaterials Science and Engineering Laboratory
Massachusetts Institute of Technology. Department of Biology
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1017/S0007114511002133
