Ligand-clustered “patchy” nanoparticles for modulated cellular uptake and in vivo tumor targeting
Author(s)Poon, Zhiyong; Chen, Shujun; Engler, Amanda C.; Lee, Hyung-il; Atas, Evrim; von Maltzahn, Geoffrey; Bhatia, Sangeeta N.; Hammond, Paula T.; ... Show more Show less
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A matter of presentation: The manner in which polyvalent ligands are presented to a cell—homogeneously or in spatially defined groupings on a nanoparticle surface—may play an important role in cellular uptake. This aspect is investigated for the first time using a linear dendritic polymer construct to pattern the surfaces of nanoparticles with variable-sized ligand clusters in different spatial arrangements.
Author Manuscript: 2012 August 05.
DepartmentHarvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Chemical Engineering
Angewandte Chemie International Edition
Poon, Zhiyong et al. “Ligand-Clustered ‘Patchy’ Nanoparticles for Modulated Cellular Uptake and In Vivo Tumor Targeting.” Angewandte Chemie International Edition 49.40 (2010): 7266–7270. Copyright © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Author's final manuscript