Ligand-clustered “patchy” nanoparticles for modulated cellular uptake and in vivo tumor targeting

Author(s)
Poon, Zhiyong; Chen, Shujun; Engler, Amanda C.; Lee, Hyung-il; Atas, Evrim; ... Show more
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Abstract
A matter of presentation: The manner in which polyvalent ligands are presented to a cell—homogeneously or in spatially defined groupings on a nanoparticle surface—may play an important role in cellular uptake. This aspect is investigated for the first time using a linear dendritic polymer construct to pattern the surfaces of nanoparticles with variable-sized ligand clusters in different spatial arrangements.
Description
Author Manuscript: 2012 August 05.
Date issued
2010-08
URI
http://hdl.handle.net/1721.1/75327
Department
Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Chemical Engineering
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Poon, Zhiyong et al. “Ligand-Clustered ‘Patchy’ Nanoparticles for Modulated Cellular Uptake and In Vivo Tumor Targeting.” Angewandte Chemie International Edition 49.40 (2010): 7266–7270. Copyright © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Version: Author's final manuscript
ISSN
1433-7851
1521-3773
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