Show simple item record

Ligand-clustered “patchy” nanoparticles for modulated cellular uptake and in vivo tumor targeting

dc.contributor.authorPoon, Zhiyong
dc.contributor.authorChen, Shujun
dc.contributor.authorEngler, Amanda C.
dc.contributor.authorLee, Hyung-il
dc.contributor.authorAtas, Evrim
dc.contributor.authorvon Maltzahn, Geoffrey
dc.contributor.authorBhatia, Sangeeta N.
dc.contributor.authorHammond, Paula T.
dc.date.accessioned2012-12-10T18:35:54Z
dc.date.available2012-12-10T18:35:54Z
dc.date.issued2010-08
dc.date.submitted2010-06
dc.identifier.issn1433-7851
dc.identifier.issn1521-3773
dc.identifier.urihttp://hdl.handle.net/1721.1/75327
dc.descriptionAuthor Manuscript: 2012 August 05.en_US
dc.description.abstractA matter of presentation: The manner in which polyvalent ligands are presented to a cell—homogeneously or in spatially defined groupings on a nanoparticle surface—may play an important role in cellular uptake. This aspect is investigated for the first time using a linear dendritic polymer construct to pattern the surfaces of nanoparticles with variable-sized ligand clusters in different spatial arrangements.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH NIBIB Grant 5R01EB008082-02)en_US
dc.description.sponsorshipMIT-Harvard Center of Cancer Nanotechnology Excellenceen_US
dc.description.sponsorshipNational Science Foundation (U.S.)en_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/anie.201003445en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePMCen_US
dc.titleLigand-clustered “patchy” nanoparticles for modulated cellular uptake and in vivo tumor targetingen_US
dc.typeArticleen_US
dc.identifier.citationPoon, Zhiyong et al. “Ligand-Clustered ‘Patchy’ Nanoparticles for Modulated Cellular Uptake and In Vivo Tumor Targeting.” Angewandte Chemie International Edition 49.40 (2010): 7266–7270. Copyright © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheimen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.mitauthorPoon, Zhiyong
dc.contributor.mitauthorChen, Shujun
dc.contributor.mitauthorEngler, Amanda C.
dc.contributor.mitauthorLee, Hyung-il
dc.contributor.mitauthorAtas, Evrim
dc.contributor.mitauthorvon Maltzahn, Geoffrey
dc.contributor.mitauthorBhatia, Sangeeta N.
dc.contributor.mitauthorHammond, Paula T.
dc.relation.journalAngewandte Chemie International Editionen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsPoon, Zhiyong; Chen, Shujun; Engler, Amanda C.; Lee, Hyung-il; Atas, Evrim; von Maltzahn, Geoffrey; Bhatia, Sangeeta N.; Hammond, Paula T.en
dc.identifier.orcidhttps://orcid.org/0000-0002-1293-2097
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


Files in this item

Thumbnail
Name:
Bhatia_Ligand-clustered.pdf
Size:
1.391Mb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record