Efficient replication bypass of size-expanded DNA base pairs in bacterial cells
Author(s)Delaney, James C.; Gao, Jianmin; Liu, Haibo; Shrivastav, Nidhi; Essigmann, John M.; Kool, Eric T.; ... Show more Show less
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Supersize me! Size-expanded DNA bases (xDNA) are able to encode natural DNA sequences in replication. In vitro experiments with a DNA polymerase show nucleotide incorporation opposite the xDNA bases with correct pairing. In vivo experiments using E. coli show that two xDNA bases (xA and xC, see picture) encode the correct replication partners.
Author Manuscript 2012 September 06
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemistry
Delaney, James C. et al. “Efficient Replication Bypass of Size-Expanded DNA Base Pairs in Bacterial Cells.” Angewandte Chemie International Edition 48.25 (2009): 4524–4527.
Author's final manuscript