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Now showing items 11-20 of 23
Strategic development of a manufacturing execution system (MES) for cold chain management using information product mapping
(Massachusetts Institute of Technology, 2011)
The Vaccines & Diagnostics (V&D) division of Novartis recently developed a global automation strategy that highlights the need to implement a manufacturing execution system (MES). Benefits of an MES (electronic production ...
Production of AAV vectors for gene therapy : a cost-effectiveness and risk assessment
(Massachusetts Institute of Technology, 2016)
Gene therapy is a promising modality for the potential treatment of rare Mendelian diseases. To date a number of high profile proof-of-concept studies within the industry have demonstrated the significant disease-correcting ...
Capacity analysis, cycle time optimization, and supply chain strategy in multi-product biopharmaceutical manufacturing operations
(Massachusetts Institute of Technology, 2011)
Application of system optimization theory, supply chain principles, and capacity modeling are increasingly valuable tools for use in pharmaceutical manufacturing facilities. The dynamics of the pharmaceutical industry - ...
Development of operations based long range network capacity planning models
(Massachusetts Institute of Technology, 2011)
Planning for vaccines manufacturing capacity is both a complex task requiring many inputs and an important function of manufacturers to ensure the supply of vaccines that prevent life-threatening illnesses. This thesis ...
Mergers and acquisitions process improvement in a matrix organization
(Massachusetts Institute of Technology, 2012)
3M has had aggressive growth through acquisitions. Almost all of the acquisitions add new manufacturing sites to the existing manufacturing and distribution networks. 3M is composed of 38 divisions (as of 2011) with ...
Feature-based investment cost estimation based on modular design of a continuous pharmaceutical manufacturing system
(Massachusetts Institute of Technology, 2011)
Previous studies of continuous manufacturing processes have used equipment-factored cost estimation methods to predict savings in initial plant investment costs. In order to challenge and validate the existing methods of ...
High reliability performance in Amgen Engineering
(Massachusetts Institute of Technology, 2012)
Amgen is in the midst of a transformative initiative to become operationally more efficient. For Amgen Engineering, this initiative has prompted a reevaluation of the entire organization and brought to light the need to ...
An equipment selection methodology for continuous manufacturing of small-molecule drugs
(Massachusetts Institute of Technology, 2019)
Flexible, modular, continuous manufacturing small-scale plants (MCSPs) for small-molecule drugs have been recognized as potential safe and economical solutions for pharmaceutical manufacturing. However, among the variety ...
Modeling and economic evaluation of early stage clinical monoclonal antibody manufacturing using single use technology
(Massachusetts Institute of Technology, 2015)
A critical cost driver in the product development process is the manufacturing of clinical trial material supplies. The clinical manufacturing process operates under similar regulatory burdens as commercial biopharmaceutical ...
Using value stream mapping to improve documentation processes in the biopharmacutical industry
(Massachusetts Institute of Technology, 2010)
This thesis describes how a 55% reduction in error rate and a 92% decrease in cycle-time were achieved in a batch production records process in a biotech manufacturing facility by utilization of value-stream mapping. The ...