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Now showing items 11-20 of 31
Analysis of outbound process defects at Amazon's ONT2 Fulfillment Center
(Massachusetts Institute of Technology, 2016)
This thesis investigated two outbound process defects that result in damaged, late, missing or wrong-item shipments, leading to a poor customer experience and concessions for Amazon. Reducing these defects will improve ...
Wires-down predictive modeling and preventative measures optimization
(Massachusetts Institute of Technology, 2016)
In 2012, the Pacific Gas and Electric Company (PG&E) identified overhead wires-down failure events as an important metric for safety and reliability. These events occur when power lines contact the ground and are caused ...
Application of continuous improvement methodologies and techniques in the Drug Design Cycle
(Massachusetts Institute of Technology, 2016)
Amgen, one of the world's leaders in biotechnology, is currently investing in ways to better serve its patients by providing new drugs sooner, and to ensure its competitiveness for years to come. One way is to increase the ...
Applying factory physics to manual assembly at an aerospace fabrication site
(Massachusetts Institute of Technology, 2017)
The assembly of welded reservoirs at the Boeing Tube Duct, and Reservoir Center (TDRC) is a traditional batch and queue operation that relies heavily on manual craftsmanship. The production system experiences high variability ...
Impulse mixer technology reliability and redesign improvement in biotechnology drug substance manufacturing
(Massachusetts Institute of Technology, 2016)
Objective: In place of traditional stainless steel systems, the "Flexible Manufacturing" technology used at Amgen employs the impulse mixer single-use system, a bag technology, to house the product and serve as the locale ...
A data-driven approach to vendor rationalization and engagement for sustainable supply chains
(Massachusetts Institute of Technology, 2016)
Demands for shorter lead times and smaller order quantities, a greater emphasis on sustainable sourcing, and better management of supply chain risks are challenges Li & Fung is addressing by reshaping its relationship with ...
Integrated supply and production network design
(Massachusetts Institute of Technology, 2016)
As Company X looks to improve customer service and deliver new growth opportunities, it is driving toward a more efficient, aligned and effective organization that eliminates waste through integration of its supply and ...
Patient flow optimization in the Department of Medicine at MGH
(Massachusetts Institute of Technology, 2017)
In 2015, there were approximately 17,000 General Medicine admissions in the Department of Medicine (DOM) at MGH. General Medicine patients regularly experience significant non-clinical delays caused by bed and care team ...
Cross-channel predictive analytics for retail distribution decisions
(Massachusetts Institute of Technology, 2017)
Distribution demand forecasting at Zara currently considers historical sales of products modified by expert knowledge inputs in an algorithm developed to calculate the shipment required to meet demand for the next sales ...
Assessing the impact of container marking implementation
(Massachusetts Institute of Technology, 2016)
Amgen is implementing new capabilities across the Amgen manufacturing network in order to code containers at the unit-level to reduce the possibility of mix-ups of unlabeled drug products. In order to prepare for the ...