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Now showing items 11-20 of 43
Engineering mammalian cell line to improve sialylation
(Massachusetts Institute of Technology, 2005)
One of the key problems faced by many biotechnology companies is the cleavage of terminal sialic acid on the glycans of the therapeutic glycoproteins. This is caused by the degradative action of sialidase released to ...
Chemical vapor deposition of organosilicon composite thin films for porous low-k dielectrics
(Massachusetts Institute of Technology, 2005)
Pulsed plasma enhanced chemical vapor deposition has produced organosilicon thin films with the potential use as low dielectric constant interconnect materials in microelectronic circuits. Both diethylsilane and ...
A design strategy applied to sulfur resistant lean NOx̳ automotive catalysts
(Massachusetts Institute of Technology, 2005)
Catalyst poisoning due to sulfur compounds derived from fuel sulfur presents a major challenge, intractable thus far, to development of many advanced technologies for automotive catalysts such as the lean NOx, trap. Under ...
Multi-scale analysis and simulation of powder blending in pharmaceutical manufacturing
(Massachusetts Institute of Technology, 2005)
A Multi-Scale Analysis methodology was developed and carried out for gaining fundamental understanding of the pharmaceutical powder blending process. Through experiment, analysis and computer simulations, microscopic ...
Studies of heterogeneous ice chemistry relevant to the atmosphere
(Massachusetts Institute of Technology, 2005)
(cont.) HCl-induced QLL formation at stratospheric conditions. It appears that the real part of the refractive index of the QLL formed via exposure to gas-phase HCl is closer. to that of liquid water or aqueous HCI solution ...
Stabilization of proteins against aggregation by solution additives
(Massachusetts Institute of Technology, 2005)
(cont.) additives.
Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes
(Massachusetts Institute of Technology, 2005)
We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow ...
Active hypothermic growth : a novel means for increasing total recombinant protein production by CHO cells
(Massachusetts Institute of Technology, 2005)
Recombinant human glycoproteins produced by Chinese Hamster Ovary (CHO) cells are an important class of therapeutic molecules and investigating means of improving the production rate and product quality of these glycoproteins ...
Polysiloxane-based liquid crystal block copolymers for piezoelectric and mechano-optical applications
(Massachusetts Institute of Technology, 2005)
Liquid crystal research has gained interest in a wide range of applications that go beyond displays. Some of these applications include memory devices, sensors, and variable light valves. Currently, liquid crystals in the ...
Chemical vapor deposition of conjugated polymeric thin films for photonic and electronic applications
(Massachusetts Institute of Technology, 2005)
(cont.) Conjugated polymers have delocalized electrons along the backbone, facilitating electrical conductivity. As thin films, they are integral to organic semiconductor devices emerging in the marketplace, such as flexible ...