Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

Author(s)
Zhang, Yun; Jamison, Timothy F.; Patel, Sejal; Mainolfi, Nello
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Abstract
A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.
Date issued
2010-12
URI
http://hdl.handle.net/1721.1/76277
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Zhang, Yun et al. “Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing.” Organic Letters 13.2 (2011): 280–283.
Version: Author's final manuscript
ISSN
1523-7060
1523-7052
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