Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing
Author(s)Zhang, Yun; Jamison, Timothy F.; Patel, Sejal; Mainolfi, Nello
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A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Zhang, Yun et al. “Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing.” Organic Letters 13.2 (2011): 280–283.
Author's final manuscript