Dendritic cell nediated inhibition of lentiviral infection

Author(s)
Drake, Adam; Browne, Edward P.; Phennicie, Ryan T.; Chen, Jianzhu
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Abstract
Lentiviral entry to quiescent lymphocytes represents a 'time bomb' waiting for cellular activation to spread infection. In order to undergo immune activation T cells interact with dendritic cells presenting peptide:MHC complexes 'sampling' them to look for agonist peptides and receiving survival signals from self peptides. This makes the dendritic cell:T cell interaction an ideal checkpoint to contain lentiviral infection of quiescent lypmhocytes.
Date issued
2012-09
URI
http://hdl.handle.net/1721.1/76670
Department
Koch Institute for Integrative Cancer Research at MIT
Journal
Retrovirology
Publisher
Biomed Central Ltd.
Citation
Drake, A et al. “Dendritic Cell Nediated Inhibition of Lentiviral Infection.” Retrovirology 9.Suppl 2 (2012): P178.
Version: Final published version
ISSN
1742-4690
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