Dendritic cell nediated inhibition of lentiviral infection
Author(s)Drake, Adam; Browne, Edward P.; Phennicie, Ryan T.; Chen, J.
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Lentiviral entry to quiescent lymphocytes represents a 'time bomb' waiting for cellular activation to spread infection. In order to undergo immune activation T cells interact with dendritic cells presenting peptide:MHC complexes 'sampling' them to look for agonist peptides and receiving survival signals from self peptides. This makes the dendritic cell:T cell interaction an ideal checkpoint to contain lentiviral infection of quiescent lypmhocytes.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT
Biomed Central Ltd.
Drake, A et al. “Dendritic Cell Nediated Inhibition of Lentiviral Infection.” Retrovirology 9.Suppl 2 (2012): P178.
Final published version