Toll Like receptor 7 regulates viral loads and cytokine secretion during acute retroviral infection
Author(s)Browne, Edward P.
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Background: Acute HIV infection is characterized by a high viremia accompanied by a powerful wave of pro-inflammatory cytokines that affects the subsequent course of infection and pathogenesis. Thus, understanding the mechanisms that regulate cytokine secretion and viremia is a key priority. The innate immune receptor TLR7 has been identified a retrovirus-sensing protein, and is expressed in several key immune lineages. In vitro data suggests that HIV can trigger TLR7-dependent innate immune responses, but TLR7s role in vivo is unclear.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT
Biomed Central Ltd.
Browne, Edward P. "Toll Like receptor 7 regulates viral loads and cytokine secretion during acute retroviral infection." Retrovirology 9.Suppl 2 (2012): 174.
Final published version