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dc.contributor.authorBrowne, Edward P.
dc.date.accessioned2013-01-31T16:28:21Z
dc.date.available2013-01-31T16:28:21Z
dc.date.issued2012-09
dc.identifier.issn1742-4690
dc.identifier.urihttp://hdl.handle.net/1721.1/76702
dc.description.abstractBackground: Acute HIV infection is characterized by a high viremia accompanied by a powerful wave of pro-inflammatory cytokines that affects the subsequent course of infection and pathogenesis. Thus, understanding the mechanisms that regulate cytokine secretion and viremia is a key priority. The innate immune receptor TLR7 has been identified a retrovirus-sensing protein, and is expressed in several key immune lineages. In vitro data suggests that HIV can trigger TLR7-dependent innate immune responses, but TLR7s role in vivo is unclear.en_US
dc.language.isoen_US
dc.publisherBiomed Central Ltd.en_US
dc.relation.isversionofhttp://www.retrovirology.com/content/9/S2/P174en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.sourceBioMed Centralen_US
dc.titleToll Like receptor 7 regulates viral loads and cytokine secretion during acute retroviral infectionen_US
dc.typeArticleen_US
dc.identifier.citationBrowne, Edward P. "Toll Like receptor 7 regulates viral loads and cytokine secretion during acute retroviral infection." Retrovirology 9.Suppl 2 (2012): 174.en_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorBrowne, Edward P.
dc.relation.journalRetrovirologyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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