dc.contributor.author | Browne, Edward P. | |
dc.date.accessioned | 2013-01-31T16:28:21Z | |
dc.date.available | 2013-01-31T16:28:21Z | |
dc.date.issued | 2012-09 | |
dc.identifier.issn | 1742-4690 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/76702 | |
dc.description.abstract | Background: Acute HIV infection is characterized by a high viremia accompanied by a powerful wave of pro-inflammatory cytokines that affects the subsequent course of infection and pathogenesis. Thus, understanding the mechanisms that regulate cytokine secretion and viremia is a key priority. The innate immune receptor TLR7 has been identified a retrovirus-sensing protein, and is expressed in several key immune lineages. In vitro data suggests that HIV can trigger TLR7-dependent innate immune responses, but TLR7s role in vivo is unclear. | en_US |
dc.language.iso | en_US | |
dc.publisher | Biomed Central Ltd. | en_US |
dc.relation.isversionof | http://www.retrovirology.com/content/9/S2/P174 | en_US |
dc.rights | Creative Commons Attribution | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0 | en_US |
dc.source | BioMed Central | en_US |
dc.title | Toll Like receptor 7 regulates viral loads and cytokine secretion during acute retroviral infection | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Browne, Edward P. "Toll Like receptor 7 regulates viral loads and cytokine secretion during acute retroviral infection." Retrovirology 9.Suppl 2 (2012): 174. | en_US |
dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
dc.contributor.mitauthor | Browne, Edward P. | |
dc.relation.journal | Retrovirology | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
mit.license | PUBLISHER_CC | en_US |
mit.metadata.status | Complete | |