The effect of retroactivity on the transfer function of a phosphorylation system
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It was theoretically shown that impedance-like effects, called retroactivity, in biomolecular circuits can significantly impact the behavior of a system. In this paper, we quantify the effect of retroactivity on the transfer function of a phosphorylation system after linearization of its nonlinear model about a steady state. Our analysis shows that retroactivity shifts the poles of the transfer function toward the low frequency.
Date issued
2010-10Department
Massachusetts Institute of Technology. Department of Mechanical EngineeringJournal
Proceedings of the 49th IEEE Conference on Decision and Control (CDC), 2010
Publisher
Institute of Electrical and Electronics Engineers
Citation
Del Vecchio, Domitilla. "The Effect of Retroactivity on the Transfer Function of a Phosphorylation System." In 49th IEEE Conference on Decision and Control, December 15-17, 2010, Hilton Atlanta Hotel, Atlanta, GA, USA, 2010, IEEE, Pp. 2523–2528. Web. © Copyright 2010 IEEE.
Version: Final published version
Other identifiers
INSPEC Accession Number: 11848955
ISBN
978-1-4244-7746-3
978-1-4244-7745-6
ISSN
0743-1546