The effect of retroactivity on the transfer function of a phosphorylation system
Author(s)Del Vecchio, Domitilla
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It was theoretically shown that impedance-like effects, called retroactivity, in biomolecular circuits can significantly impact the behavior of a system. In this paper, we quantify the effect of retroactivity on the transfer function of a phosphorylation system after linearization of its nonlinear model about a steady state. Our analysis shows that retroactivity shifts the poles of the transfer function toward the low frequency.
DepartmentMassachusetts Institute of Technology. Department of Mechanical Engineering
Proceedings of the 49th IEEE Conference on Decision and Control (CDC), 2010
Institute of Electrical and Electronics Engineers
Del Vecchio, Domitilla. "The Effect of Retroactivity on the Transfer Function of a Phosphorylation System." In 49th IEEE Conference on Decision and Control, December 15-17, 2010, Hilton Atlanta Hotel, Atlanta, GA, USA, 2010, IEEE, Pp. 2523–2528. Web. © Copyright 2010 IEEE.
Final published version
INSPEC Accession Number: 11848955