Fragile X mental retardation protein and synaptic plasticity

Author(s)
Sidorov, Michael Samuel; Auerbach, Benjamin David; Bear, Mark
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Abstract
Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.
Date issued
2013-04
URI
http://hdl.handle.net/1721.1/78638
Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Picower Institute for Learning and Memory
Journal
Molecular Brain
Publisher
BioMed Central Ltd
Citation
Sidorov, Michael S, Benjamin D Auerbach, and Mark F Bear. “Fragile X Mental Retardation Protein and Synaptic Plasticity.” Molecular Brain 6.1 (2013): 15.
Version: Final published version
ISSN
1756-6606
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