Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels
Author(s)Rhee, Minsoung; Valencia, Pedro Miguel; Rodriguez, Maria I.; Langer, Robert; Farokhzad, Omid C.; Karnik, Rohit; ... Show more Show less
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A versatile microfluidic platform to synthesize NPs by nanoprecipitation using 3D hydrodynamic flow focusing isolates the precipitating precursors from channel walls, eliminating fouling of the channels. It is shown that this new method enables robust nanoprecipitation without polymer aggregation, regardless of the polymer molecular weight or precursor concentration implemented, where the size of the resulting polymeric NPs is tunable.
Author Manuscript date: 2011 June 27
Departmentdelete; David H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Department of Mechanical Engineering
Rhee, Minsoung, Pedro M. Valencia, Maria I. Rodriguez, et al. 2011Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels. Advanced Materials 23(12): H79–H83.
Author's final manuscript