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Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels

dc.contributor.authorRhee, Minsoung
dc.contributor.authorValencia, Pedro Miguel
dc.contributor.authorRodriguez, Maria I.
dc.contributor.authorLanger, Robert
dc.contributor.authorFarokhzad, Omid C.
dc.contributor.authorKarnik, Rohit
dc.date.accessioned2013-05-13T18:22:33Z
dc.date.available2013-05-13T18:22:33Z
dc.date.issued2011-02
dc.date.submitted2010-12
dc.identifier.issn0935-9648
dc.identifier.issn1521-4095
dc.identifier.urihttp://hdl.handle.net/1721.1/78861
dc.descriptionAuthor Manuscript date: 2011 June 27en_US
dc.description.abstractA versatile microfluidic platform to synthesize NPs by nanoprecipitation using 3D hydrodynamic flow focusing isolates the precipitating precursors from channel walls, eliminating fouling of the channels. It is shown that this new method enables robust nanoprecipitation without polymer aggregation, regardless of the polymer molecular weight or precursor concentration implemented, where the size of the resulting polymeric NPs is tunable.en_US
dc.description.sponsorshipDavid H. Koch (Prostate Cancer Foundation Award in Nanotherapeutics)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant CA119349)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Graduate Research Fellowship)en_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/adma.201004333en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePubMed Centralen_US
dc.titleSynthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannelsen_US
dc.typeArticleen_US
dc.identifier.citationRhee, Minsoung, Pedro M. Valencia, Maria I. Rodriguez, et al. 2011Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels. Advanced Materials 23(12): H79–H83.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorRhee, Minsoung
dc.contributor.mitauthorValencia, Pedro Miguel
dc.contributor.mitauthorRodriguez, Maria I.
dc.contributor.mitauthorLanger, Robert
dc.contributor.mitauthorKarnik, Rohit
dc.relation.journalAdvanced Materialsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsRhee, Minsoung; Valencia, Pedro M.; Rodriguez, Maria I.; Langer, Robert; Farokhzad, Omid C.; Karnik, Rohiten
dc.identifier.orcidhttps://orcid.org/0000-0003-0588-9286
dc.identifier.orcidhttps://orcid.org/0000-0003-4255-0492
dspace.mitauthor.errortrue
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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