Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany

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Grad, Y. H.; Lipsitch, M.; Griggs, Allison; Haas, Brian J.; Shea, T. P.; ... Show more
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Abstract
In our paper (1), we analyzed isolates from the Escherichia coli O104:H4 outbreaks in Germany and France in May to July 2011. We concluded that, although the German outbreak was larger, the German isolates represent a clade within the greater diversity of the French outbreak. We proposed several hypotheses to explain these findings, including that the lineage leading to the German outbreak went through a narrow bottleneck that purged diversity. Guy et al. (2) report the genomes of eight additional E. coli O104:H4 isolates sampled from the German outbreak. By focusing on the numbers of SNPs in their samples, they suggest that the German outbreak is more diverse than we reported and is similar to the French outbreak. In fact, Guy et al.’s data (2) strongly support our conclusion that the German outbreak represents a clade within the diversity …
Date issued
2012-12
URI
http://hdl.handle.net/1721.1/79083
Department
Massachusetts Institute of Technology. Department of Biology
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Grad, Y. H., M. Lipsitch, A. D. Griggs, B. J. Haas, T. P. Shea, C. McCowan, A. Montmayeur, et al. Reply to Guy Et Al.: Support for a Bottleneck in the 2011 Escherichia Coli O104:H4 Outbreak in Germany. Proceedings of the National Academy of Sciences 109, no. 52 (December 26, 2012): E3629-E3630.
Version: Final published version
ISSN
0027-8424
1091-6490
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