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Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany

dc.contributor.authorGrad, Y. H.
dc.contributor.authorLipsitch, M.
dc.contributor.authorGriggs, Allison
dc.contributor.authorHaas, Brian J.
dc.contributor.authorShea, T. P.
dc.contributor.authorMcCowan, C.
dc.contributor.authorMontmayeur, A.
dc.contributor.authorFitzGerald, M.
dc.contributor.authorWortman, J. R.
dc.contributor.authorKrogfelt, K. A.
dc.contributor.authorBingen, E.
dc.contributor.authorWeill, F.-X.
dc.contributor.authorTietze, E.
dc.contributor.authorFlieger, A.
dc.contributor.authorNusbaum, Chad
dc.contributor.authorBirren, Bruce W.
dc.contributor.authorHung, Deborah T.
dc.contributor.authorHanage, W. P.
dc.date.accessioned2013-06-10T18:28:05Z
dc.date.available2013-06-10T18:28:05Z
dc.date.issued2012-12
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/1721.1/79083
dc.description.abstractIn our paper (1), we analyzed isolates from the Escherichia coli O104:H4 outbreaks in Germany and France in May to July 2011. We concluded that, although the German outbreak was larger, the German isolates represent a clade within the greater diversity of the French outbreak. We proposed several hypotheses to explain these findings, including that the lineage leading to the German outbreak went through a narrow bottleneck that purged diversity. Guy et al. (2) report the genomes of eight additional E. coli O104:H4 isolates sampled from the German outbreak. By focusing on the numbers of SNPs in their samples, they suggest that the German outbreak is more diverse than we reported and is similar to the French outbreak. In fact, Guy et al.’s data (2) strongly support our conclusion that the German outbreak represents a clade within the diversity …en_US
dc.language.isoen_US
dc.publisherNational Academy of Sciences (U.S.)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1073/pnas.1209419110en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePNASen_US
dc.titleReply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germanyen_US
dc.typeArticleen_US
dc.identifier.citationGrad, Y. H., M. Lipsitch, A. D. Griggs, B. J. Haas, T. P. Shea, C. McCowan, A. Montmayeur, et al. Reply to Guy Et Al.: Support for a Bottleneck in the 2011 Escherichia Coli O104:H4 Outbreak in Germany. Proceedings of the National Academy of Sciences 109, no. 52 (December 26, 2012): E3629-E3630.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorLander, Eric S.en_US
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsGrad, Y. H.; Lipsitch, M.; Griggs, A. D.; Haas, B. J.; Shea, T. P.; McCowan, C.; Montmayeur, A.; FitzGerald, M.; Wortman, J. R.; Krogfelt, K. A.; Bingen, E.; Weill, F.-X.; Tietze, E.; Flieger, A.; Lander, E. S.; Nusbaum, C.; Birren, B. W.; Hung, D. T.; Hanage, W. P.en_US
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mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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