Nano-Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA

Author(s)
DeMuth, Peter Charles; Su, Xingfang; Samuel, Raymond E.; Hammond, Paula T.; Irvine, Darrell J.
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Abstract
Multilayer-coated microneedles achieve transcutaneous delivery of plasmid DNA to the viable epidermis. Cy3-labeled plasmid DNA encoding luciferase (yellow) is deposited on biodegradable microneedle arrays through multilayer self-assembly and then delivered to the skin by microneedle application to achieve colocalization with Langerhans dendritic cells (MHC II-GFP–green).
Date issued
2010-11
URI
http://hdl.handle.net/1721.1/79375
Department
Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies; David H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Materials Science and Engineering; Ragon Institute of MGH, MIT and Harvard
Journal
Advanced Materials
Publisher
Wiley-Blackwell Publishers
Citation
DeMuth, Peter C., Xingfang Su, Raymond E. Samuel, Paula T. Hammond, and Darrell J. Irvine. Nano-Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA. Advanced Materials 22, no. 43 (November 16, 2010): 4851-4856.
Version: Author's final manuscript
ISSN
09359648
1521-4095
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