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dc.contributor.authorDeMuth, Peter Charles
dc.contributor.authorSu, Xingfang
dc.contributor.authorSamuel, Raymond E.
dc.contributor.authorHammond, Paula T.
dc.contributor.authorIrvine, Darrell J.
dc.date.accessioned2013-06-26T16:33:34Z
dc.date.available2013-06-26T16:33:34Z
dc.date.issued2010-11
dc.date.submitted2010-07
dc.identifier.issn09359648
dc.identifier.issn1521-4095
dc.identifier.urihttp://hdl.handle.net/1721.1/79375
dc.description.abstractMultilayer-coated microneedles achieve transcutaneous delivery of plasmid DNA to the viable epidermis. Cy3-labeled plasmid DNA encoding luciferase (yellow) is deposited on biodegradable microneedle arrays through multilayer self-assembly and then delivered to the skin by microneedle application to achieve colocalization with Langerhans dendritic cells (MHC II-GFP–green).en_US
dc.description.sponsorshipUnited States. Dept. of Defense (DAAD19- 02-D-0002)en_US
dc.description.sponsorshipUnited States. Dept. of Defense (W911NF-07-D-0004)en_US
dc.description.sponsorshipRagon Institute of MGH, MIT and Harvarden_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH Biotechnology Training Program at MIT)en_US
dc.description.sponsorshipHoward Hughes Medical Institute (Investigator)en_US
dc.language.isoen_US
dc.publisherWiley-Blackwell Publishersen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/adma.201001525en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePMCen_US
dc.titleNano-Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNAen_US
dc.typeArticleen_US
dc.identifier.citationDeMuth, Peter C., Xingfang Su, Raymond E. Samuel, Paula T. Hammond, and Darrell J. Irvine. Nano-Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA. Advanced Materials 22, no. 43 (November 16, 2010): 4851-4856.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Soldier Nanotechnologiesen_US
dc.contributor.departmentDavid H. Koch Institute for Integrative Cancer Research at MITen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.departmentRagon Institute of MGH, MIT and Harvarden_US
dc.contributor.mitauthorDeMuth, Peter Charlesen_US
dc.contributor.mitauthorSu, Xingfangen_US
dc.contributor.mitauthorSamuel, Raymond E.en_US
dc.contributor.mitauthorHammond, Paula T.en_US
dc.contributor.mitauthorIrvine, Darrell J.en_US
dc.relation.journalAdvanced Materialsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsDeMuth, Peter C.; Su, Xingfang; Samuel, Raymond E.; Hammond, Paula T.; Irvine, Darrell J.en_US
mit.licenseOPEN_ACCESS_POLICYen_US


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