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dc.contributor.authorKodandaramaiah, Suhasa Bangalo
dc.contributor.authorTalei Franzesi, Giovanni
dc.contributor.authorChow, Brian Y.
dc.contributor.authorBoyden, Edward Stuart
dc.contributor.authorForest, Craig R.
dc.date.accessioned2013-07-16T21:38:18Z
dc.date.available2013-07-16T21:38:18Z
dc.date.issued2012-05
dc.identifier.issn1548-7091
dc.identifier.issn1548-7105
dc.identifier.urihttp://hdl.handle.net/1721.1/79604
dc.description.abstractWhole-cell patch-clamp electrophysiology of neurons is a gold-standard technique for high-fidelity analysis of the biophysical mechanisms of neural computation and pathology, but it requires great skill to perform. We have developed a robot that automatically performs patch clamping in vivo, algorithmically detecting cells by analyzing the temporal sequence of electrode impedance changes. We demonstrate good yield, throughput and quality of automated intracellular recording in mouse cortex and hippocampus.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH EUREKA Award program (1R01NS075421))en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) ((NIH) Director′s New Innovator Award (DP2OD002002)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) ((NSF) CAREER award (CBET 1053233))en_US
dc.description.sponsorshipNew York Stem Cell Foundation (Robertson Neuroscience Award)en_US
dc.description.sponsorshipDr. Gerald Burnett and Marjorie Burnetten_US
dc.description.sponsorshipNational Science Foundation (U.S.) (grant CISE 1110947)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (grant EHR 0965945)en_US
dc.description.sponsorshipAmerican Heart Association (10GRNT4430029)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/nmeth.1993en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.rights.urien_US
dc.sourcePMCen_US
dc.titleAutomated whole-cell patch-clamp electrophysiology of neurons in vivoen_US
dc.typeArticleen_US
dc.identifier.citationKodandaramaiah, Suhasa B, Giovanni Talei Franzesi, Brian Y Chow, Edward S Boyden, and Craig R Forest. Automated Whole-cell Patch-clamp Electrophysiology of Neurons in Vivo. Nature Methods 9, no. 6 (May 6, 2012): 585-587.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Media Laboratoryen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.departmentProgram in Media Arts and Sciences (Massachusetts Institute of Technology)en_US
dc.contributor.mitauthorKodandaramaiah, Suhasa Bangaloen_US
dc.contributor.mitauthorTalei Franzesi, Giovannien_US
dc.contributor.mitauthorChow, Brian Y.en_US
dc.contributor.mitauthorBoyden, Edward Stuarten_US
dc.relation.journalNature Methodsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsKodandaramaiah, Suhasa B; Franzesi, Giovanni Talei; Chow, Brian Y; Boyden, Edward S; Forest, Craig Ren_US
dc.identifier.orcidhttps://orcid.org/0000-0003-2218-7489
dc.identifier.orcidhttps://orcid.org/0000-0002-0419-3351
dc.identifier.orcidhttps://orcid.org/0000-0001-7132-8706
mit.licensePUBLISHER_POLICYen_US


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