| dc.contributor.author | Kodandaramaiah, Suhasa Bangalo | |
| dc.contributor.author | Talei Franzesi, Giovanni | |
| dc.contributor.author | Forest, Craig R. | |
| dc.contributor.author | Chow, Brian Yichiun | |
| dc.contributor.author | Boyden, Edward | |
| dc.date.accessioned | 2013-07-16T21:38:18Z | |
| dc.date.available | 2013-07-16T21:38:18Z | |
| dc.date.issued | 2012-05 | |
| dc.identifier.issn | 1548-7091 | |
| dc.identifier.issn | 1548-7105 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/79604 | |
| dc.description.abstract | Whole-cell patch-clamp electrophysiology of neurons is a gold-standard technique for high-fidelity analysis of the biophysical mechanisms of neural computation and pathology, but it requires great skill to perform. We have developed a robot that automatically performs patch clamping in vivo, algorithmically detecting cells by analyzing the temporal sequence of electrode impedance changes. We demonstrate good yield, throughput and quality of automated intracellular recording in mouse cortex and hippocampus. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH EUREKA Award program (1R01NS075421)) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) ((NIH) Director′s New Innovator Award (DP2OD002002) | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.) ((NSF) CAREER award (CBET 1053233)) | en_US |
| dc.description.sponsorship | New York Stem Cell Foundation (Robertson Neuroscience Award) | en_US |
| dc.description.sponsorship | Dr. Gerald Burnett and Marjorie Burnett | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.) (grant CISE 1110947) | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.) (grant EHR 0965945) | en_US |
| dc.description.sponsorship | American Heart Association (10GRNT4430029) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Nature Publishing Group | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1038/nmeth.1993 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.rights.uri | | en_US |
| dc.source | PMC | en_US |
| dc.title | Automated whole-cell patch-clamp electrophysiology of neurons in vivo | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Kodandaramaiah, Suhasa B, Giovanni Talei Franzesi, Brian Y Chow, Edward S Boyden, and Craig R Forest. Automated Whole-cell Patch-clamp Electrophysiology of Neurons in Vivo. Nature Methods 9, no. 6 (May 6, 2012): 585-587. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Media Laboratory | en_US |
| dc.contributor.department | McGovern Institute for Brain Research at MIT | en_US |
| dc.contributor.department | Program in Media Arts and Sciences (Massachusetts Institute of Technology) | en_US |
| dc.contributor.mitauthor | Kodandaramaiah, Suhasa Bangalo | en_US |
| dc.contributor.mitauthor | Talei Franzesi, Giovanni | en_US |
| dc.contributor.mitauthor | Chow, Brian Y. | en_US |
| dc.contributor.mitauthor | Boyden, Edward Stuart | en_US |
| dc.relation.journal | Nature Methods | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Kodandaramaiah, Suhasa B; Franzesi, Giovanni Talei; Chow, Brian Y; Boyden, Edward S; Forest, Craig R | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0003-2218-7489 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-0419-3351 | |
| dc.identifier.orcid | https://orcid.org/0000-0001-7132-8706 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
